ENSMUSG00000026253


Mus musculus

Features
Gene ID: ENSMUSG00000026253
  
Biological name :Chrng
  
Synonyms : cholinergic receptor, nicotinic, gamma polypeptide / Chrng
  
Possible biological names infered from orthology : cholinergic receptor nicotinic gamma subunit / P07510
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 87204657
Gene end: 87212694
  
Corresponding Affymetrix probe sets: 10348166 (MoGene1.0st)   1427728_at (Mouse Genome 430 2.0 Array)   1449532_at (Mouse Genome 430 2.0 Array)   1452520_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027470
Ensembl peptide - ENSMUSP00000139600
Ensembl peptide - ENSMUSP00000140796
Ensembl peptide - ENSMUSP00000141001
NCBI entrez gene - 11449     See in Manteia.
MGI - MGI:87895
RefSeq - XM_006529078
RefSeq - NM_009604
RefSeq Peptide - NP_033734
swissprot - I0B502
swissprot - F8VQK4
swissprot - A0A087WP27
swissprot - H8YHW6
Ensembl - ENSMUSG00000026253
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrngENSDARG00000086647Danio rerio
 CHRNGENSGALG00000007906Gallus gallus
 CHRNGENSG00000196811Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrne / P20782 / cholinergic receptor, nicotinic, epsilon polypeptide / Q04844* / cholinergic receptor nicotinic epsilon subunit*ENSMUSG0000001460949
Chrnd / P02716 / cholinergic receptor, nicotinic, delta polypeptide / Q07001* / cholinergic receptor nicotinic delta subunit*ENSMUSG0000002625147
Chrnb1 / P09690 / cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) / P11230* / cholinergic receptor nicotinic beta 1 subunit*ENSMUSG0000004118939
Chrna7 / P49582 / cholinergic receptor, nicotinic, alpha polypeptide 7 / P36544* / cholinergic receptor nicotinic alpha 7 subunit*ENSMUSG0000003052530
Chrna9 / cholinergic receptor, nicotinic, alpha polypeptide 9 / Q9UGM1* / cholinergic receptor nicotinic alpha 9 subunit*ENSMUSG0000002920527
Chrna10 / cholinergic receptor, nicotinic, alpha polypeptide 10 / Q9GZZ6* / cholinergic receptor nicotinic alpha 10 subunit*ENSMUSG0000006627926
Htr3a / 5-hydroxytryptamine (serotonin) receptor 3A / P46098* / 5-hydroxytryptamine receptor 3A*ENSMUSG0000003226919
Htr3b / Q9JHJ5 / 5-hydroxytryptamine (serotonin) receptor 3B / O95264* / 5-hydroxytryptamine receptor 3B*ENSMUSG0000000859017


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IEA


Pathways (from Reactome)
Pathway description
Highly sodium permeable acetylcholine nicotinic receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
Show

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

Allelic Composition: Chrngtm2(Chrne)Vwi/Chrngtm2(Chrne)Vwi
Genetic Background: involves: C57BL/6

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: NOD.129S2-Cd28tm1Mak

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: B6.129-Rcan2tm1Ypt

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: NOD.129S2-Cd28tm1Mak

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

Allelic Composition: Chrngtm2(Chrne)Vwi/Chrngtm2(Chrne)Vwi
Genetic Background: involves: C57BL/6

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Chrngtm2(Chrne)Vwi/Chrngtm2(Chrne)Vwi
Genetic Background: involves: C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Socs7tm1Pbro/Socs7tm1Pbro
Genetic Background: B6.129S1-Socs7tm1Pbro

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak
Genetic Background: NOD.129S2-Cd28tm1Mak

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032303 Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*  / complex
 ENSMUSG00000035200 Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*  / complex






 

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