ENSMUSG00000066279


Mus musculus

Features
Gene ID: ENSMUSG00000066279
  
Biological name :Chrna10
  
Synonyms : cholinergic receptor, nicotinic, alpha polypeptide 10 / Chrna10
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 10 subunit / Q9GZZ6
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 102111266
Gene end: 102116828
  
Corresponding Affymetrix probe sets: 10566091 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000081891
Ensembl peptide - ENSMUSP00000147577
NCBI entrez gene - 504186     See in Manteia.
MGI - MGI:3609260
RefSeq - NM_001081424
RefSeq - XM_006508008
RefSeq - XM_006508009
RefSeq Peptide - NP_001074893
swissprot - B2RX82
swissprot - A0A1B0GRL8
Ensembl - ENSMUSG00000066279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9GZZ6ENSG00000129749Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrna9 / cholinergic receptor, nicotinic, alpha polypeptide 9 / Q9UGM1* / cholinergic receptor nicotinic alpha 9 subunit*ENSMUSG0000002920555
Chrna7 / P49582 / cholinergic receptor, nicotinic, alpha polypeptide 7 / P36544* / cholinergic receptor nicotinic alpha 7 subunit*ENSMUSG0000003052539
Chrnb1 / P09690 / cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) / P11230* / cholinergic receptor nicotinic beta 1 subunit*ENSMUSG0000004118932
Chrne / P20782 / cholinergic receptor, nicotinic, epsilon polypeptide / Q04844* / cholinergic receptor nicotinic epsilon subunit*ENSMUSG0000001460930
Chrng / cholinergic receptor, nicotinic, gamma polypeptide / P07510* / cholinergic receptor nicotinic gamma subunit*ENSMUSG0000002625330
Chrnd / P02716 / cholinergic receptor, nicotinic, delta polypeptide / Q07001* / cholinergic receptor nicotinic delta subunit*ENSMUSG0000002625129
Htr3a / 5-hydroxytryptamine (serotonin) receptor 3A / P46098* / 5-hydroxytryptamine receptor 3A*ENSMUSG0000003226928
Htr3b / Q9JHJ5 / 5-hydroxytryptamine (serotonin) receptor 3B / O95264* / 5-hydroxytryptamine receptor 3B*ENSMUSG0000000859020


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0007271 synaptic transmission, cholinergic IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IMP
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

 MP:0004432 abnormal cochlear hair cell physiology "anomalies in processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

 MP:0004433 abnormal cochlear inner hair cell physiology "anomalies in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

 MP:0004434 abnormal cochlear outer hair cell physiology "anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

 MP:0004632 abnormal cochlear OHC efferent innervation "any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

 MP:0004633 abnormal cochlear IHC efferent innervation "any changes in the morphology of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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