ENSMUSG00000030525


Mus musculus

Features
Gene ID: ENSMUSG00000030525
  
Biological name :Chrna7
  
Synonyms : cholinergic receptor, nicotinic, alpha polypeptide 7 / Chrna7 / P49582
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 7 subunit / P36544
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: C
Gene start: 63098692
Gene end: 63212569
  
Corresponding Affymetrix probe sets: 10564272 (MoGene1.0st)   1440681_at (Mouse Genome 430 2.0 Array)   1450299_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032738
NCBI entrez gene - 11441     See in Manteia.
MGI - MGI:99779
RefSeq - NM_007390
RefSeq Peptide - NP_031416
swissprot - P49582
swissprot - Q53YJ9
Ensembl - ENSMUSG00000030525
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrna7ENSDARG00000101702Danio rerio
 FO907089.1ENSDARG00000101522Danio rerio
 CHRNA7ENSGALG00000004096Gallus gallus
 CHRNA7ENSG00000175344Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrna10 / cholinergic receptor, nicotinic, alpha polypeptide 10 / Q9GZZ6* / cholinergic receptor nicotinic alpha 10 subunit*ENSMUSG0000006627935
Chrna9 / cholinergic receptor, nicotinic, alpha polypeptide 9 / Q9UGM1* / cholinergic receptor nicotinic alpha 9 subunit*ENSMUSG0000002920533
Chrng / cholinergic receptor, nicotinic, gamma polypeptide / P07510* / cholinergic receptor nicotinic gamma subunit*ENSMUSG0000002625331
Chrnb1 / P09690 / cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) / P11230* / cholinergic receptor nicotinic beta 1 subunit*ENSMUSG0000004118931
Chrnd / P02716 / cholinergic receptor, nicotinic, delta polypeptide / Q07001* / cholinergic receptor nicotinic delta subunit*ENSMUSG0000002625130
Chrne / P20782 / cholinergic receptor, nicotinic, epsilon polypeptide / Q04844* / cholinergic receptor nicotinic epsilon subunit*ENSMUSG0000001460928
Htr3a / 5-hydroxytryptamine (serotonin) receptor 3A / P46098* / 5-hydroxytryptamine receptor 3A*ENSMUSG0000003226925
Htr3b / Q9JHJ5 / 5-hydroxytryptamine (serotonin) receptor 3B / O95264* / 5-hydroxytryptamine receptor 3B*ENSMUSG0000000859019


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001988 positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IMP
 biological_processGO:0006811 ion transport IMP
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0007271 synaptic transmission, cholinergic IMP
 biological_processGO:0007611 learning or memory IGI
 biological_processGO:0007613 memory IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0009409 response to cold IDA
 biological_processGO:0014061 regulation of norepinephrine secretion IMP
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0032094 response to food IMP
 biological_processGO:0032222 regulation of synaptic transmission, cholinergic IC
 biological_processGO:0032225 regulation of synaptic transmission, dopaminergic IMP
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0034220 ion transmembrane transport ISO
 biological_processGO:0035094 response to nicotine IGI
 biological_processGO:0035095 behavioral response to nicotine IGI
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0042113 B cell activation IMP
 biological_processGO:0042391 regulation of membrane potential ISO
 biological_processGO:0042698 ovulation cycle IMP
 biological_processGO:0045471 response to ethanol IMP
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048149 behavioral response to ethanol IMP
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050804 modulation of chemical synaptic transmission IGI
 biological_processGO:0050808 synapse organization IGI
 biological_processGO:0050890 cognition IEA
 biological_processGO:0050893 sensory processing IDA
 biological_processGO:0051247 positive regulation of protein metabolic process IGI
 biological_processGO:0051823 regulation of synapse structural plasticity IC
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060112 generation of ovulation cycle rhythm IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0097061 dendritic spine organization IMP
 biological_processGO:0098815 modulation of excitatory postsynaptic potential IGI
 biological_processGO:0140059 dendrite arborization IMP
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IGI
 biological_processGO:1901214 regulation of neuron death IGI
 biological_processGO:1902004 positive regulation of amyloid-beta formation IGI
 biological_processGO:1902430 negative regulation of amyloid-beta formation IEA
 biological_processGO:1902991 regulation of amyloid precursor protein catabolic process IEA
 biological_processGO:1904645 response to amyloid-beta IMP
 biological_processGO:1905144 response to acetylcholine IEA
 biological_processGO:1905906 regulation of amyloid fibril formation IGI
 biological_processGO:1905920 positive regulation of CoA-transferase activity IGI
 biological_processGO:1905923 positive regulation of acetylcholine biosynthetic process IC
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IGI
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005892 acetylcholine-gated channel complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030673 axolemma IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098793 presynapse TAS
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity ISO
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015464 acetylcholine receptor activity IEA
 molecular_functionGO:0015643 toxic substance binding IEA
 molecular_functionGO:0017081 chloride channel regulator activity IEA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity ISO
 molecular_functionGO:0042166 acetylcholine binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrna7tm2Bay/Chrna7tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrna7tm2Bay/Chrna7tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000950 pharmacologically induced seizures "seizure activity that is brought about by treatment with pharmacological agents" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001054 failure of presynaptic differentiation "inability of nerve terminals to find target and/or form terminal arbors for synaptic transmission" [J:61509]
Show

Allelic Composition: Chattm1Fhg/Chattm1Fhg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Agrntm4Jrs/Agrntm4Jrs,Chrna1tm1Klee/Chrna1tm1Klee,Chrna7tm1Bay/Chrna7tm1Bay
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Chrna7tm2Bay/Chrna7tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Vamp1lew/Vamp1lew
Genetic Background: involves: C3H/HeSnJ * CAST/EiJ

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Chrna7tm2Bay/Chrna7tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid,Snai3tm1.2Jhws/Snai3+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Chrna7tm1.1Ehs/Chrna7tm1.1Ehs,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: B6.Cg-Chrna7tm1.1Ehs Tg(Gfap-cre)77.6Mvs

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Irf3tm1Ttg/Irf3tm1Ttg,Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Chrna7tm2Bay/Chrna7tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003257 abnormal abdominal wall "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003450 enlarged pancreas "increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006408 dorsal root ganglion hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, of a dorsal root ganglion or ganglia" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chrna7tm1Bay/Chrna7+
Genetic Background: B6.129S7-Chrna7tm1Bay/J

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeN

Allelic Composition: Chrna7tm1Bay/Chrna7+
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeN

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009475 abnormal nicotine-mediated receptor currents "change in the measured amplitude, current density or duration of response to stimulation of nicotinic receptors" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Chrna7tm2Bay/Chrna7tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009516 enlarged salivary gland "increased size of the saliva-secreting glands of the oral cavity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Chrna7tm2Bay/Chrna7tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011114 abnormal airway basal cell differentiation "abnormal or arrest of differentiation of the long-lived multipotent stem cell population of the pseudostratified airway epithelium; changes in the lineage choice of BCs or their undifferentiated daughters might contribute to the mucous cell hyperplasia, metaplasia or squamous metaplasia seen in many respiratory disorders" [MGI:anna, PMID:17909629]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0011115 airway basal cell hyperplasia "increased number of the long-lived multipotent stem cells of the pseudostratified airway epithelium" [MGI:anna]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0011179 decreased erythroblast number "reduced number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0011987 abnormal GABAergic neuron physiology "any functional anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter" [PMID:8787741]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012174 flat head "the appearance of a flattened surface outline or contour of a normally rounded head of an organism" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012709 delayed caudal neuropore closure "a delay in the joining together of the neural folds of the caudal opening of the neural tube" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030091 macrodontia "abnormal increase in the size of one or more teeth" [HP:0001572, MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr