ENSMUSG00000026335
Mus musculus copper process Pam ii activity binding type response protein membrane metabolic ion development lyase regulation n-terminal peptidylglycine nhl repeat domain superfamily histidine-cluster- conserved site c-terminal peptide amidation acid plasma
Features See expression report in BioGPS See gene description in Wikigenes See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl ) Dbh / Q64237 / Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase / P09172* / dopamine beta-hydroxylase* ENSMUSG00000000889 11 Moxd1 / Q9CXI3 / DBH-like monooxygenase protein 1 / Q6UVY6* / monooxygenase DBH like 1* ENSMUSG00000020000 10 Moxd2 / Q7TT41 / DBH-like monooxygenase protein 2 ENSMUSG00000029885 10
Protein motifs (from Interpro ) IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal IPR000720 Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase IPR001258 NHL repeat IPR008977 PHM/PNGase F domain superfamily IPR011042 Six-bladed beta-propeller, TolB-like IPR013017 NHL repeat, subgroup IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminal IPR036939 Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Gene Ontology (GO ) nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrogen compound metabolic process cellular metabolic process organic substance metabolic process response to stress response to abiotic stimulus primary metabolic process small molecule metabolic process biosynthetic process anatomical structure development establishment of localization regulation of biological quality secondary metabolic process multicellular organism reproduction response to endogenous stimulus response to chemical cellular component organization actin filament-based process macromolecule localization cellular component biogenesis oxidation-reduction process multi-multicellular organism process nitrognitrogen compound metabolic process cellulcellular metabolic process organiorganic substance metabolic process responresponse to stress responresponse to abiotic stimulus primarprimary metabolic process small small molecule metabolic process biosynbiosynthetic process anatomanatomical structure development establestablishment of localization regularegulation of biological quality secondsecondary metabolic process multicmulticellular organism reproduction responresponse to endogenous stimulus responresponse to chemical cellulcellular component organization actin actin filament-based process macrommacromolecule localization cellulcellular component biogenesis oxidatoxidation-reduction process multi-multi-multicellular organism process oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase activity lyase activity catalytic activity, acting on a protein ion binding protein binding carbohydrate binding cofactor binding small molecule binding oxidoreductase acoxidoreductase activity lyase activitylyase activity catalytic activitcatalytic activity, acting on a protein ion bindingion binding protein bindingprotein binding carbohydrate bindcarbohydrate binding cofactor bindingcofactor binding small molecule bismall molecule binding extracellular region cell organelle membrane extracellular region cell organelle membrane extracellular region cell organelle membrane extracellular region cell organelle membrane extracellular region cell organelle membrane extracellular region cell organelle membrane extracellular region cell organelle membrane extracellular region cell organelle membrane extracellular region cell organelle membrane extracellular region cell organelle membrane extracellular regionextracellular region cellcell organelleorganelle membranemembrane
Pathways (from Reactome )No match Phenotype (from MGI , Zfin or HPO ) homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism phenotype cardiovascular system phenotype embryogenesis phenotype adipose tissue phenotype respiratory system phenotype mortality/aging homeostasis/metabolism homeostasis/metabolism phenotype cardiovascular system pcardiovascular system phenotype embryogenesis phenotypeembryogenesis phenotype adipose tissue phenotypadipose tissue phenotype respiratory system phenrespiratory system phenotype mortality/agingmortality/aging MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show
Allelic Composition: Fgf8tm1.4Mrt /Fgf8+ ,Tbx1tm1Bld /Tbx1+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR
MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show
Allelic Composition: Fgf8tm1.4Mrt /Fgf8+ ,Tbx1tm1Bld /Tbx1+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR
MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show
Allelic Composition: Fgf8tm1.4Mrt /Fgf8+ ,Tbx1tm1Bld /Tbx1+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR
MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show
Allelic Composition: Fgf8tm1.4Mrt /Fgf8+ ,Tbx1tm1Bld /Tbx1+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICRAllelic Composition: Pamtm1Jep /Pam+ Genetic Background: involves: 129S7/SvEvBrd
MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show
Allelic Composition: Pamtm1Jep /Pam+ Genetic Background: involves: 129S7/SvEvBrd
MP:0010943 abnormal bronchus epithelium morphology "any structural anomaly of the epithelial layer of the bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show
Allelic Composition: Fgf8tm1.4Mrt /Fgf8+ ,Tbx1tm1Bld /Tbx1+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR
MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show
Allelic Composition: Fgf8tm1.4Mrt /Fgf8+ ,Tbx1tm1Bld /Tbx1+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR
MP:0012303 umbilical vein stenosis "abnormal constriction or narrowing of the unpaired umbilical vein that carries oxygenated, nutrient-rich blood from the placenta to the fetus" [MGI:anna]
Show
Allelic Composition: Fgf8tm1.4Mrt /Fgf8+ ,Tbx1tm1Bld /Tbx1+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR
Interacting proteins (from Reactome )No match
0 s.
