ENSMUSG00000026335


Mus musculus

Features
Gene ID: ENSMUSG00000026335
  
Biological name :Pam
  
Synonyms : P97467 / Pam / peptidylglycine alpha-amidating monooxygenase
  
Possible biological names infered from orthology : P19021
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: D
Gene start: 97795114
Gene end: 98095646
  
Corresponding Affymetrix probe sets: 10356968 (MoGene1.0st)   1418908_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125418
Ensembl peptide - ENSMUSP00000124479
Ensembl peptide - ENSMUSP00000125133
Ensembl peptide - ENSMUSP00000057112
Ensembl peptide - ENSMUSP00000095228
Ensembl peptide - ENSMUSP00000124284
NCBI entrez gene - 18484     See in Manteia.
MGI - MGI:97475
RefSeq - XM_017319290
RefSeq - XM_011247937
RefSeq - XM_011247938
RefSeq - XM_011247939
RefSeq - XM_017319280
RefSeq - XM_017319282
RefSeq - XM_017319284
RefSeq - XM_017319286
RefSeq - XM_017319289
RefSeq - NM_001357127
RefSeq - NM_013626
RefSeq - XM_006529243
RefSeq - XM_006529244
RefSeq Peptide - NP_001344056
RefSeq Peptide - NP_038654
swissprot - F8VQA4
swissprot - F6T0D3
swissprot - F6TGI4
swissprot - E9Q704
swissprot - P97467
swissprot - F7D4K4
Ensembl - ENSMUSG00000026335
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pamENSDARG00000100170Danio rerio
 PAMENSGALG00000015256Gallus gallus
 PAMENSG00000145730Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dbh / Q64237 / Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase / P09172* / dopamine beta-hydroxylase*ENSMUSG0000000088911
Moxd1 / Q9CXI3 / DBH-like monooxygenase protein 1 / Q6UVY6* / monooxygenase DBH like 1*ENSMUSG0000002000010
Moxd2 / Q7TT41 / DBH-like monooxygenase protein 2 ENSMUSG0000002988510


Protein motifs (from Interpro)
Interpro ID Name
 IPR000323  Copper type II, ascorbate-dependent monooxygenase, N-terminal
 IPR000720  Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
 IPR001258  NHL repeat
 IPR008977  PHM/PNGase F domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013017  NHL repeat, subgroup
 IPR014783  Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
 IPR014784  Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
 IPR020611  Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
 IPR024548  Copper type II ascorbate-dependent monooxygenase, C-terminal
 IPR036939  Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001519 peptide amidation IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001676 long-chain fatty acid metabolic process IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006518 peptide metabolic process IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0009404 toxin metabolic process IEA
 biological_processGO:0018032 protein amidation IEA
 biological_processGO:0019538 protein metabolic process IEA
 biological_processGO:0022602 ovulation cycle process IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0050708 regulation of protein secretion IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0060173 limb development IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004504 peptidylglycine monooxygenase activity IEA
 molecular_functionGO:0004598 peptidylamidoglycolate lyase activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

Allelic Composition: Pamtm1Jep/Pam+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pamtm1Jep/Pam+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010943 abnormal bronchus epithelium morphology "any structural anomaly of the epithelial layer of the bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0012303 umbilical vein stenosis "abnormal constriction or narrowing of the unpaired umbilical vein that carries oxygenated, nutrient-rich blood from the placenta to the fetus" [MGI:anna]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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