ENSMUSG00000020000


Mus musculus

Features
Gene ID: ENSMUSG00000020000
  
Biological name :Moxd1
  
Synonyms : DBH-like monooxygenase protein 1 / Moxd1 / Q9CXI3
  
Possible biological names infered from orthology : monooxygenase DBH like 1 / Q6UVY6
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A4
Gene start: 24223517
Gene end: 24302790
  
Corresponding Affymetrix probe sets: 10362186 (MoGene1.0st)   1422643_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093460
NCBI entrez gene - 59012     See in Manteia.
MGI - MGI:1921582
RefSeq - NM_021509
RefSeq Peptide - NP_067484
swissprot - Q9CXI3
Ensembl - ENSMUSG00000020000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 moxd1ENSDARG00000031136Danio rerio
 MOXD1ENSGALG00000002911Gallus gallus
 MOXD1ENSG00000079931Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Moxd2 / Q7TT41 / DBH-like monooxygenase protein 2 ENSMUSG0000002988532
Dbh / Q64237 / Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase / P09172* / dopamine beta-hydroxylase*ENSMUSG0000000088929
Pam / P97467 / peptidylglycine alpha-amidating monooxygenase / P19021*ENSMUSG0000002633515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000323  Copper type II, ascorbate-dependent monooxygenase, N-terminal
 IPR005018  DOMON domain
 IPR008977  PHM/PNGase F domain superfamily
 IPR014784  Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
 IPR024548  Copper type II ascorbate-dependent monooxygenase, C-terminal
 IPR028460  Tyramine beta-hydroxylase/Dopamine beta-hydroxylase
 IPR028463  DBH-like monooxygenase protein 1
 IPR036939  Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006589 octopamine biosynthetic process IBA
 biological_processGO:0042420 dopamine catabolic process IBA
 biological_processGO:0042421 norepinephrine biosynthetic process IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0016020 membrane ISM
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004500 dopamine beta-monooxygenase activity IBA
 molecular_functionGO:0005507 copper ion binding IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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