ENSMUSG00000000889


Mus musculus

Features
Gene ID: ENSMUSG00000000889
  
Biological name :Dbh
  
Synonyms : Dbh / Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase / Q64237
  
Possible biological names infered from orthology : dopamine beta-hydroxylase / P09172
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 27165233
Gene end: 27183200
  
Corresponding Affymetrix probe sets: 10470412 (MoGene1.0st)   1447592_at (Mouse Genome 430 2.0 Array)   1450670_at (Mouse Genome 430 2.0 Array)   1459848_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000910
NCBI entrez gene - 13166     See in Manteia.
MGI - MGI:94864
RefSeq - NM_138942
RefSeq Peptide - NP_620392
swissprot - Q64237
Ensembl - ENSMUSG00000000889
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dbhENSDARG00000069446Danio rerio
 DBHENSGALG00000040045Gallus gallus
 DBHENSG00000123454Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Moxd1 / Q9CXI3 / DBH-like monooxygenase protein 1 / Q6UVY6* / monooxygenase DBH like 1*ENSMUSG0000002000028
Moxd2 / Q7TT41 / DBH-like monooxygenase protein 2 ENSMUSG0000002988528
Pam / P97467 / peptidylglycine alpha-amidating monooxygenase / P19021*ENSMUSG0000002633517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000323  Copper type II, ascorbate-dependent monooxygenase, N-terminal
 IPR005018  DOMON domain
 IPR008977  PHM/PNGase F domain superfamily
 IPR014783  Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
 IPR014784  Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
 IPR020611  Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
 IPR024548  Copper type II ascorbate-dependent monooxygenase, C-terminal
 IPR028460  Tyramine beta-hydroxylase/Dopamine beta-hydroxylase
 IPR036939  Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0002443 leukocyte mediated immunity IMP
 biological_processGO:0006589 octopamine biosynthetic process IBA
 biological_processGO:0007613 memory IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042309 homoiothermy IMP
 biological_processGO:0042420 dopamine catabolic process IEA
 biological_processGO:0042421 norepinephrine biosynthetic process ISS
 biological_processGO:0042423 catecholamine biosynthetic process IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042596 fear response IMP
 biological_processGO:0042711 maternal behavior IMP
 biological_processGO:0045907 positive regulation of vasoconstriction IMP
 biological_processGO:0048149 behavioral response to ethanol IMP
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:2001236 regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034466 chromaffin granule lumen IEA
 cellular_componentGO:0034774 secretory granule lumen IEA
 cellular_componentGO:0042584 chromaffin granule membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004500 dopamine beta-monooxygenase activity ISO
 molecular_functionGO:0005507 copper ion binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Catecholamine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001428 adipsia "absence of thirst or lack of desire to drink " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001443 poor grooming "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001462 abnormal avoidance learning behavior "defects in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dbhtm2(Th)Rpa/Dbhtm2(Th)Rpa
Genetic Background: Not Specified

 MP:0001742 absent circulating adrenaline "lack of a catacholamine hormone that stimulates the adrenergic receptors and causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:24414]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001743 absent circulating noradrenaline "lack of this catacholamine hormone that is secreted in response to hypoactivity or physical stress in the blood; used as a vasoconstrictor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:24414]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dbhtm1Rpa/Dbhtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * 129/SvCPJ * C57BL/6J

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mavstm1Zjc/Mavs+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl14tm1.1Rih/Cxcl14tm1.1Rih
Genetic Background: involves: C57BL/6

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dbhtm1Rpa/Dbhtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * 129/SvCPJ * C57BL/6J

 MP:0002711 decreased glucagon secretion "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dbhtm1Rpa/Dbhtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * 129/SvCPJ * C57BL/6J

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002822 catalepsy "a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003908 decreased stereotypic behavior "less frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [RGD:Rat Genome Database submission]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Dbhtm1Rpa/Dbh+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dbhtm1Rpa/Dbhtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * 129/SvCPJ * C57BL/6J

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dbhtm1Rpa/Dbhtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * 129/SvCPJ * C57BL/6J

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dbhtm1Rpa/Dbhtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * 129/SvCPJ * C57BL/6J

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lin28atm2.1Gqda/Lin28atm2.1Gqda,Lin28btm2.1Gqda/Lin28btm2.1Gqda
Genetic Background: STOCK Lin28atm2.1Gqda Lin28btm2.1Gqda/J

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl14tm1.1Rih/Cxcl14tm1.1Rih
Genetic Background: involves: C57BL/6

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cxcl14tm1.1Rih/Cxcl14tm1.1Rih
Genetic Background: involves: C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dbhtm2(Th)Rpa/Dbhtm2(Th)Rpa
Genetic Background: Not Specified

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
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Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm1Rpa/Thtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dbhtm2(Th)Rpa/Dbh+,Thtm5Rpa/Thtm5Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Dbhtm1Rpa/Dbh+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000889 Dbh / Q64237 / Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase / P09172* / dopamine beta-hydroxylase*  / complex






 

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