ENSDARG00000069446


Danio rerio

Features
Gene ID: ENSDARG00000069446
  
Biological name :dbh
  
Synonyms : dbh / dopamine beta-hydroxylase (dopamine beta-monooxygenase)
  
Possible biological names infered from orthology : dopamine beta-hydroxylase / Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase / P09172 / Q64237
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 10564261
Gene end: 10607118
  
Corresponding Affymetrix probe sets: Dr.21021.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000091863
NCBI entrez gene - 30505     See in Manteia.
RefSeq - NM_001109694
RefSeq Peptide - NP_001103164
swissprot - B3DGL8
ZFIN ID - ZDB-GENE-990621-3
Ensembl - ENSDARG00000069446
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DBHENSGALG00000040045Gallus gallus
 DBHENSG00000123454Homo sapiens
 DbhENSMUSG00000000889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
moxd1 / Q5TZ24 / monooxygenase, DBH-like 1 / Q6UVY6* / Q9CXI3* / DBH-like monooxygenase protein 1 *ENSDARG0000003113627
moxd1l / monooxygenase, DBH-like 1, like / Moxd2* / Q7TT41* / DBH-like monooxygenase protein 2 *ENSDARG0000006929625
pam / peptidylglycine alpha-amidating monooxygenase / P19021* / P97467*ENSDARG0000010017016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000323  Copper type II, ascorbate-dependent monooxygenase, N-terminal
 IPR005018  DOMON domain
 IPR008977  PHM/PNGase F domain superfamily
 IPR014783  Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
 IPR014784  Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
 IPR024548  Copper type II ascorbate-dependent monooxygenase, C-terminal
 IPR028460  Tyramine beta-hydroxylase/Dopamine beta-hydroxylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006589 octopamine biosynthetic process IBA
 biological_processGO:0030431 sleep IMP
 biological_processGO:0042420 dopamine catabolic process IBA
 biological_processGO:0042421 norepinephrine biosynthetic process IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004500 dopamine beta-monooxygenase activity IBA
 molecular_functionGO:0005507 copper ion binding IBA
 molecular_functionGO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA


Pathways (from Reactome)
Pathway description
Catecholamine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000069446 dbh / dopamine beta-hydroxylase (dopamine beta-monooxygenase) / Q64237* / P09172* / dopamine beta-hydroxylase* / Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase*  / complex






 

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