ENSMUSG00000027077


Mus musculus

Features
Gene ID: ENSMUSG00000027077
  
Biological name :Smtnl1
  
Synonyms : Q99LM3 / Smoothelin-like protein 1 / Smtnl1
  
Possible biological names infered from orthology : A8MU46 / smoothelin like 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: D
Gene start: 84811176
Gene end: 84822652
  
Corresponding Affymetrix probe sets: 10484472 (MoGene1.0st)   1419145_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028471
NCBI entrez gene - 68678     See in Manteia.
MGI - MGI:1915928
RefSeq - NM_024230
RefSeq - XM_006500109
RefSeq Peptide - NP_077192
swissprot - Q99LM3
Ensembl - ENSMUSG00000027077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smtnaENSDARG00000074652Danio rerio
 ENSGALG00000011865Gallus gallus
 A8MU46ENSG00000214872Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smtn / Q921U8 / Smoothelin / P53814*ENSMUSG0000002043928
Q8CI12 / Smtnl2 / Smoothelin-like protein 2 / Q2TAL5* / smoothelin like 2*ENSMUSG0000004566722
Ehbp1l1 / EH domain-binding protein 1-like protein 1 isoform C / Q8N3D4* / EH domain binding protein 1 like 1*ENSMUSG0000002493717
Ehbp1 / Q69ZW3 / EH domain-binding protein 1 / Q8NDI1*ENSMUSG0000004230214
Mical3 / Q8CJ19 / [F-actin]-monooxygenase MICAL3 / Q7RTP6* / microtubule associated monooxygenase, calponin and LIM domain containing 3*ENSMUSG0000005158613
Q8BML1 / Mical2 / [F-actin]-monooxygenase MICAL2 / O94851* / Q6ZW33* / microtubule associated monooxygenase, calponin and LIM domain containing 2*ENSMUSG0000003824412
Mical1 / Q8VDP3 / Mus musculus microtubule associated monooxygenase, calponin and LIM domain containing 1 (Mical1), transcript variant 4, mRNA. / Q8TDZ2* / microtubule associated monooxygen...ENSMUSG0000001982311
Q8BGT6 / Micall1 / MICAL-like protein 1 / Q8N3F8* / MICAL like 1*ENSMUSG000000330399
Q3TN34 / Micall2 / MICAL-like protein 2 / Q8IY33* / MICAL like 2*ENSMUSG000000367189
Q2KN98 / Specc1l / sperm antigen with calponin homology and coiled-coil domains 1-like / Q69YQ0* / SPECC1L-ADORA2A* / SPECC1L-ADORA2A readthrough (NMD candidate)*ENSMUSG000000334446
Q9D5U9 / Micalcl / MICAL C-terminal-like protein ENSMUSG000000307715
Q5SXY1 / Specc1 / sperm antigen with calponin homology and coiled-coil domains 1 / Q5M775*ENSMUSG000000423315
AC132392.1ENSMUSG000001111875


Protein motifs (from Interpro)
Interpro ID Name
 IPR001715  Calponin homology domain
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0014823 response to activity IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045907 positive regulation of vasoconstriction IMP
 biological_processGO:0048644 muscle organ morphogenesis IMP
 biological_processGO:0097756 negative regulation of blood vessel diameter IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031430 M band IDA
 cellular_componentGO:0031674 I band IEA
 cellular_componentGO:0043292 contractile fiber ISO
 molecular_functionGO:0004864 protein phosphatase inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IPI
 molecular_functionGO:0005523 tropomyosin binding IPI
 molecular_functionGO:0008157 protein phosphatase 1 binding IPI
 molecular_functionGO:0017020 myosin phosphatase regulator activity ISO
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0051401 CH domain binding IPI
 molecular_functionGO:0097718 disordered domain specific binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0012107 enhanced exercise endurance "improved performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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