ENSMUSG00000027079


Mus musculus

Features
Gene ID: ENSMUSG00000027079
  
Biological name :Clp1
  
Synonyms : Clp1 / Polyribonucleotide 5-hydroxyl-kinase Clp1 / Q99LI9
  
Possible biological names infered from orthology : cleavage and polyadenylation factor I subunit 1 / Q92989
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: D
Gene start: 84722104
Gene end: 84727350
  
Corresponding Affymetrix probe sets: 10484457 (MoGene1.0st)   1423612_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028475
Ensembl peptide - ENSMUSP00000129300
NCBI entrez gene - 98985     See in Manteia.
MGI - MGI:2138968
RefSeq - NM_133840
RefSeq Peptide - NP_598601
swissprot - Q99LI9
Ensembl - ENSMUSG00000027079
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clp1ENSDARG00000063663Danio rerio
 CLP1ENSGALG00000007370Gallus gallus
 CLP1ENSG00000172409Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010655  Pre-mRNA cleavage complex subunit Clp1, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028606  Polyribonucleotide 5-hydroxyl-kinase Clp1
 IPR032319  Polyribonucleotide 5"-hydroxyl-kinase Clp1, P-loop domain
 IPR032324  Clp1, N-terminal beta-sandwich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006378 mRNA polyadenylation IBA
 biological_processGO:0006379 mRNA cleavage IBA
 biological_processGO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021695 cerebellar cortex development IEA
 biological_processGO:0030423 targeting of mRNA for destruction involved in RNA interference IEA
 biological_processGO:0031124 mRNA 3"-end processing IEA
 biological_processGO:0035087 siRNA loading onto RISC involved in RNA interference IEA
 cellular_componentGO:0000214 tRNA-intron endonuclease complex IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005849 mRNA cleavage factor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046404 ATP-dependent polydeoxyribonucleotide 5"-hydroxyl-kinase activity IEA
 molecular_functionGO:0051731 polynucleotide 5"-hydroxyl-kinase activity IBA
 molecular_functionGO:0051733 polydeoxyribonucleotide kinase activity IEA
 molecular_functionGO:0051736 ATP-dependent polyribonucleotide 5"-hydroxyl-kinase activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
mRNA Splicing - Major Pathway
mRNA 3-end processing
Processing of Intronless Pre-mRNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0001080 defasiculated phrenic nerve "misprojection or failure to bundle motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mmp21b2b2458Clo/Mmp21b2b2458Clo
Genetic Background: C57BL/6J-Mmp21b2b2458Clo

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Zic3Ka/Y
Genetic Background: B6.C(C3H)-Zic3Ka

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034820 Cpsf7 / Q8BTV2 / Cleavage and polyadenylation specificity factor subunit 7 / Q8N684* / cleavage and polyadenylation specific factor 7*  / complex
 ENSMUSG00000031754 Nudt21 / Q9CQF3 / nudix (nucleoside diphosphate linked moiety X)-type motif 21 / O43809* / nudix hydrolase 21*  / complex
 ENSMUSG00000041328 Pcf11 / PCF11 cleavage and polyadenylation factor subunit / O94913*  / complex






 

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