ENSMUSG00000027257


Mus musculus

Features
Gene ID: ENSMUSG00000027257
  
Biological name :Pacsin3
  
Synonyms : Pacsin3 / Protein kinase C and casein kinase II substrate protein 3 / Q99JB8
  
Possible biological names infered from orthology : protein kinase C and casein kinase substrate in neurons 3 / Q9UKS6
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E1
Gene start: 91255954
Gene end: 91264679
  
Corresponding Affymetrix probe sets: 10473861 (MoGene1.0st)   1416995_at (Mouse Genome 430 2.0 Array)   1437834_s_at (Mouse Genome 430 2.0 Array)   1456191_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117214
Ensembl peptide - ENSMUSP00000129175
Ensembl peptide - ENSMUSP00000122779
Ensembl peptide - ENSMUSP00000122769
Ensembl peptide - ENSMUSP00000121297
Ensembl peptide - ENSMUSP00000118915
Ensembl peptide - ENSMUSP00000117230
Ensembl peptide - ENSMUSP00000028694
Ensembl peptide - ENSMUSP00000054391
Ensembl peptide - ENSMUSP00000106981
Ensembl peptide - ENSMUSP00000115046
NCBI entrez gene - 80708     See in Manteia.
MGI - MGI:1891410
RefSeq - XM_006500428
RefSeq - NM_001289677
RefSeq - NM_001289678
RefSeq - NM_028733
RefSeq - NM_030880
RefSeq - XM_006500424
RefSeq - XM_006500425
RefSeq - XM_006500427
RefSeq Peptide - NP_001276606
RefSeq Peptide - NP_001276607
RefSeq Peptide - NP_083009
RefSeq Peptide - NP_112019
swissprot - B1AW92
swissprot - B1AW91
swissprot - A6PWR1
swissprot - F6W8Y8
swissprot - B1AW94
swissprot - B1AW93
swissprot - Q99JB8
swissprot - B1AW95
swissprot - Q543N7
Ensembl - ENSMUSG00000027257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pacsin3ENSDARG00000099339Danio rerio
 PACSIN3ENSGALG00000008231Gallus gallus
 Q9UKS6ENSG00000165912Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WVE8 / Pacsin2 / protein kinase C and casein kinase substrate in neurons 2 / Q9UNF0*ENSMUSG0000001666457
Q61644 / Pacsin1 / Protein kinase C and casein kinase substrate in neurons protein 1 / Q9BY11* / protein kinase C and casein kinase substrate in neurons 1*ENSMUSG0000004027650


Protein motifs (from Interpro)
Interpro ID Name
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR027267  AH/BAR domain superfamily
 IPR028523  Protein kinase C and casein kinase substrate in neurons protein 3
 IPR031160  F-BAR domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045806 negative regulation of endocytosis IMP
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis ISO
 biological_processGO:0051926 negative regulation of calcium ion transport IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0097320 plasma membrane tubulation ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IDA
 molecular_functionGO:0008289 lipid binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019855 calcium channel inhibitor activity IMP


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027257 Q99JB8 / Pacsin3 / Protein kinase C and casein kinase II substrate protein 3 / Q9UKS6* / protein kinase C and casein kinase substrate in neurons 3*  / complex






 

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