ENSMUSG00000027524


Mus musculus

Features
Gene ID: ENSMUSG00000027524
  
Biological name :Edn3
  
Synonyms : Edn3 / Endothelin-3 / P48299
  
Possible biological names infered from orthology : P14138
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 174760619
Gene end: 174784042
  
Corresponding Affymetrix probe sets: 10479165 (MoGene1.0st)   1421136_at (Mouse Genome 430 2.0 Array)   1438696_at (Mouse Genome 430 2.0 Array)   1441923_s_at (Mouse Genome 430 2.0 Array)   1441924_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029030
Ensembl peptide - ENSMUSP00000125602
NCBI entrez gene - 13616     See in Manteia.
MGI - MGI:95285
RefSeq - NM_007903
RefSeq Peptide - NP_031929
swissprot - E0CZ86
swissprot - A2APU5
swissprot - P48299
Ensembl - ENSMUSG00000027524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR855375.3ENSDARG00000109591Danio rerio
 edn3bENSDARG00000086669Danio rerio
 EDN3ENSGALG00000040880Gallus gallus
 EDN3ENSG00000124205Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Edn1 / P22387 / Endothelin-1 Big endothelin-1 / P05305* / endothelin 1*ENSMUSG0000002136723
Edn2 / P22389 / Endothelin-2 / P20800*ENSMUSG0000002863523


Protein motifs (from Interpro)
Interpro ID Name
 IPR001928  Endothelin-like toxin
 IPR019764  Endothelin-like toxin, conserved site
 IPR020475  Endothelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis ISO
 biological_processGO:0003100 regulation of systemic arterial blood pressure by endothelin ISO
 biological_processGO:0006874 cellular calcium ion homeostasis IGI
 biological_processGO:0007166 cell surface receptor signaling pathway ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010460 positive regulation of heart rate ISO
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010961 cellular magnesium ion homeostasis IGI
 biological_processGO:0014826 vein smooth muscle contraction ISO
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0030072 peptide hormone secretion ISO
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030318 melanocyte differentiation IDA
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0042310 vasoconstriction ISO
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0045597 positive regulation of cell differentiation ISO
 biological_processGO:0045840 positive regulation of mitotic nuclear division ISO
 biological_processGO:0046887 positive regulation of hormone secretion ISO
 biological_processGO:0048016 inositol phosphate-mediated signaling ISO
 biological_processGO:0048070 regulation of developmental pigmentation IMP
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005179 hormone activity ISO
 molecular_functionGO:0031708 endothelin B receptor binding ISO


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001048 absent enteric neurons "missing neurons that innervate the esophagus, stomach, small and large bowel" [Principles of Neural Science:ISBN 0-8385-8034-3, J:49471]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002926 aganglionic megacolon "extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002940 variable body spotting "the appearance of patches of white fur at random on the coat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Edn3ls/Edn3ls
Genetic Background: involves: C57BL

Allelic Composition: Edn3tmgc48/Edn3tmgc48
Genetic Background: C57BL/6-19PWK

Allelic Composition: Edn3tmgc48/Edn3+
Genetic Background: C57BL/6-19PWK

 MP:0005075 abnormal melanosome morphology "anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]
Show

Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Edn3ls/Edn3+
Genetic Background: involves: C57BL

 MP:0009783 abnormal melanoblast morphology "any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [CL:0000541]
Show

Allelic Composition: Edn3ls/Edn3ls
Genetic Background: involves: C57BL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Edn3ls/Edn3ls
Genetic Background: involves: C57BL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Edn3tmgc48/Edn3tmgc48
Genetic Background: C57BL/6-19PWK

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015342 Xk / Q9QXY7 / X-linked Kx blood group / P51811*  / reaction
 ENSMUSG00000022122 Ednrb / P48302 / Endothelin receptor type B / P24530*  / complex / reaction
 ENSMUSG00000031616 Ednra / Q61614 / Endothelin-1 receptor / P25101* / endothelin receptor type A*  / complex / reaction
 ENSMUSG00000029866 Kel / Q9EQF2 / Kell blood group glycoprotein homolog / P23276* / Kell blood group, metallo-endopeptidase*  / reaction






 

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