ENSDARG00000086669


Danio rerio
endothelin-liketoxinedn3bconservedsiteendothelinregulationvasoconstrictiondifferentiationpigmentcelldevelopmentextracellularregionpeptideligand-bindingreceptorsgalphaqsignallingeventswholeorganismdorsallarvalmelanophorestripe

Features
Gene ID: ENSDARG00000086669
  
Biological name :edn3b
  
Synonyms : edn3b / endothelin 3b
  
Possible biological names infered from orthology : EDN3 / endothelin 3 / P14138 / P48299
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 12072980
Gene end: 12106839
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000115695
NCBI entrez gene - 100148183     See in Manteia.
swissprot - E9QFS0
ZFIN ID - ZDB-GENE-090313-235
Ensembl - ENSDARG00000086669
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EDN3ENSGALG00000040880Gallus gallus
 EDN3ENSG00000124205Homo sapiens
 Edn3ENSMUSG00000027524Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
edn1 / endothelin 1 / P05305* / P22387* / Endothelin-1 Big endothelin-1*ENSDARG0000003691229
si:ch211-202p1.5ENSDARG0000009675527
edn2 / endothelin 2 / P20800* / P22389*ENSDARG0000007057825
CR855375.3 / EDN3* / P14138* / endothelin 3*ENSDARG0000010959122


Protein motifs (from Interpro)
Interpro ID Name
 IPR001928  Endothelin-like toxin
 IPR019764  Endothelin-like toxin, conserved site
 IPR020475  Endothelin


Gene Ontology (GO)
regulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological qualitysystem processcellular developmental processdevelopmental pigmentationanatomical structure developmentregulation of biological quaregulation of biological qualitysystem processsystem processcellular developmental procecellular developmental processdevelopmental pigmentationdevelopmental pigmentationanatomical structure developanatomical structure development
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0070285 pigment cell development IMP
 cellular_componentGO:0005576 extracellular region IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism decreased life span , ameliorated
whole organism neoplasm increased amount , abnormal
whole organism melanoma increased amount , ameliorated
Show

 ZFA:0005221 dorsal larval melanophore stripe dorsal larval melanophore stripe lacks parts or has fewer parts of type iridophore , abnormal
Show

 ZFA:0009091 melanocyte melanocyte shape , abnormal
melanocyte decreased amount , abnormal
melanocyte decreased pigmentation , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011876 ednraa / endothelin receptor type Aa / EDNRA* / P25101* / Q61614* / Endothelin-1 receptor * / endothelin receptor type A*  / complex / reaction
 ENSDARG00000056618 xk / X-linked Kx blood group (McLeod syndrome) / P51811* / Q9QXY7* / X-linked Kx blood group*  / reaction
 ENSDARG00000089334 ednrba / endothelin receptor Ba / EDNRB* / P24530* / endothelin receptor type B*  / complex / reaction
 ENSDARG00000062262 ednrab / endothelin receptor type Ab / EDNRA* / P25101* / Q61614* / Endothelin-1 receptor * / endothelin receptor type A*  / complex / reaction
 ENSDARG00000076950 kel / Kell blood group, metallo-endopeptidase / P23276* / Q9EQF2* / Kell blood group glycoprotein homolog *  / reaction






 

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