ENSMUSG00000028020


Mus musculus

Features
Gene ID: ENSMUSG00000028020
  
Biological name :Glrb
  
Synonyms : Glrb / Glycine receptor subunit beta / P48168
  
Possible biological names infered from orthology : glycine receptor beta / P48167
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 80843599
Gene end: 80913660
  
Corresponding Affymetrix probe sets: 10498907 (MoGene1.0st)   1422504_at (Mouse Genome 430 2.0 Array)   1459850_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142306
Ensembl peptide - ENSMUSP00000029654
Ensembl peptide - ENSMUSP00000103372
Ensembl peptide - ENSMUSP00000115014
Ensembl peptide - ENSMUSP00000116604
NCBI entrez gene - 14658     See in Manteia.
MGI - MGI:95751
RefSeq - XM_017319461
RefSeq - XM_006501006
RefSeq - XM_011240017
RefSeq - XM_011240018
RefSeq - XM_017319457
RefSeq - XM_017319458
RefSeq - XM_017319459
RefSeq - XM_017319460
RefSeq - NM_001281969
RefSeq - NM_010298
RefSeq - XM_006501003
RefSeq Peptide - NP_001268898
RefSeq Peptide - NP_034428
swissprot - E9PV81
swissprot - E9Q9K1
swissprot - A1KR23
swissprot - P48168
swissprot - E9Q3E3
Ensembl - ENSMUSG00000028020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glrbaENSDARG00000052782Danio rerio
 glrbbENSDARG00000052769Danio rerio
 GLRBENSGALG00000009395Gallus gallus
 GLRBENSG00000109738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Glra2 / Q7TNC8 / Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript variant 3, mRNA. / P23416* / glycine receptor alpha 2*ENSMUSG0000001858944
Glra3 / glycine receptor alpha 3 / O75311*ENSMUSG0000003825744
Glra4 / Q61603 / Glycine receptor subunit alpha-4 / Q5JXX5* / glycine receptor alpha 4*ENSMUSG0000001859543
Glra1 / Q64018 / Glycine receptor subunit alpha-1 / P23415* / glycine receptor alpha 1*ENSMUSG0000000026341
Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*ENSMUSG0000000765330
Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*ENSMUSG0000002921230
Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*ENSMUSG0000003134429
Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*ENSMUSG0000003367629
Gabrr2 / P56476 / Gamma-aminobutyric acid receptor subunit rho-2 / P28476* / gamma-aminobutyric acid type A receptor rho2 subunit*ENSMUSG0000002326728
Gabrr1 / P56475 / Gamma-aminobutyric acid receptor subunit rho-1 / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*ENSMUSG0000002828028
Gabrr3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) / A8MPY1*ENSMUSG0000007499127
Gabrp / Q8QZW7 / Gamma-aminobutyric acid receptor subunit pi / O00591* / gamma-aminobutyric acid type A receptor pi subunit*ENSMUSG0000002015925
Gabrd / P22933 / Gamma-aminobutyric acid receptor subunit delta / O14764* / gamma-aminobutyric acid type A receptor delta subunit*ENSMUSG0000002905425


Protein motifs (from Interpro)
Interpro ID Name
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008060  Glycine receptor beta
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001964 startle response IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007340 acrosome reaction IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0043200 response to amino acid IBA
 biological_processGO:0050905 neuromuscular process IMP
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0060012 synaptic transmission, glycinergic IMP
 biological_processGO:0060013 righting reflex IMP
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0097112 gamma-aminobutyric acid receptor clustering IGI
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane ISA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016935 glycine-gated chloride channel complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0098982 GABA-ergic synapse IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IPI
 molecular_functionGO:0016594 glycine binding IEA
 molecular_functionGO:0016933 extracellularly glycine-gated ion channel activity ISS
 molecular_functionGO:0016934 extracellularly glycine-gated chloride channel activity IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Glra1spd/Glra1spd
Genetic Background: B6C3Fe a/a-Glra1spd/J

Allelic Composition: Glrbspa/Glrb+
Genetic Background: B6C3Fe a/a-Glrbspa/J

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

Allelic Composition: Glrbspa/Glrbspa,Tg(Eno2-Glrb)456Wha/Tg(Eno2-Glrb)456Wha
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Glrbspa/Glrbspa,Tg(Eno2-Glrb)456Wha/0
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Glrbspa/Glrbspa
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Glrbspa/Glrbspa,Tg(Eno2-Glrb)456Wha/0
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Glrbspa/Glrbspa
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

Allelic Composition: Glrbspa/Glrbspa,Tg(Eno2-Glrb)456Wha/Tg(Eno2-Glrb)456Wha
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Glrbspa/Glrbspa,Tg(Eno2-Glrb)456Wha/0
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Glrbspa/Glrbspa
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

Allelic Composition: Glrbspa/Glrbspa,Tg(Eno2-Glrb)456Wha/0
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Glrbspa/Glrbspa
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: B6.Cg-Mcm4chaos3 Mcm4Gt(RRE056)Byg

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

Allelic Composition: Glrbspa/Glrbspa,Tg(Eno2-Glrb)456Wha/0
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Glrbspa/Glrbspa
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

 MP:0004173 abnormal intervertebral disk morphology "malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Glra1spd/Glra1spd
Genetic Background: B6C3Fe a/a-Glra1spd/J

Allelic Composition: Glrbspa/Glrb+
Genetic Background: B6C3Fe a/a-Glrbspa/J

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0005604 hyperekplexia "disorder characterized by pathologic startle responses, protective reactions to unanticipated, potentially threatening, stimuli of any type, particularly auditory" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

Allelic Composition: Glrbspa/Glrbspa,Tg(Eno2-Glrb)456Wha/0
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Glrbspa/Glrbspa
Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0009025 abnormal brain dura mater morphology "any structural anomaly of the fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Plagl1tm1Jour/Plagl1+
Genetic Background: CBA.129P2-Plagl1tm1Jour

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038257 Glra3 / glycine receptor alpha 3 / O75311*  / complex
 ENSMUSG00000018589 Glra2 / Q7TNC8 / Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript variant 3, mRNA. / P23416* / glycine receptor alpha 2*  / complex
 ENSMUSG00000000263 Glra1 / Q64018 / Glycine receptor subunit alpha-1 / P23415* / glycine receptor alpha 1*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr