ENSMUSG00000029212


Mus musculus

Features
Gene ID: ENSMUSG00000029212
  
Biological name :Gabrb1
  
Synonyms : Gabrb1 / Gamma-aminobutyric acid receptor subunit beta-1 / P50571
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor beta1 subunit / P18505
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.2
Gene start: 71658113
Gene end: 72149037
  
Corresponding Affymetrix probe sets: 10522324 (MoGene1.0st)   1419719_at (Mouse Genome 430 2.0 Array)   1435095_at (Mouse Genome 430 2.0 Array)   1443205_at (Mouse Genome 430 2.0 Array)   1443834_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031122
Ensembl peptide - ENSMUSP00000143682
NCBI entrez gene - 14400     See in Manteia.
MGI - MGI:95619
RefSeq - XM_006503736
RefSeq - NM_008069
RefSeq Peptide - NP_032095
swissprot - P50571
swissprot - Q53WT3
swissprot - A0A0G2JGS8
Ensembl - ENSMUSG00000029212
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabrb1ENSDARG00000076127Danio rerio
 GABRB1ENSG00000163288Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*ENSMUSG0000000765380
Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*ENSMUSG0000003367675
Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*ENSMUSG0000003134442
Gabrp / Q8QZW7 / Gamma-aminobutyric acid receptor subunit pi / O00591* / gamma-aminobutyric acid type A receptor pi subunit*ENSMUSG0000002015937
Gabrr1 / P56475 / Gamma-aminobutyric acid receptor subunit rho-1 / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*ENSMUSG0000002828037
Glra4 / Q61603 / Glycine receptor subunit alpha-4 / Q5JXX5* / glycine receptor alpha 4*ENSMUSG0000001859536
Gabrd / P22933 / Gamma-aminobutyric acid receptor subunit delta / O14764* / gamma-aminobutyric acid type A receptor delta subunit*ENSMUSG0000002905436
Gabrr2 / P56476 / Gamma-aminobutyric acid receptor subunit rho-2 / P28476* / gamma-aminobutyric acid type A receptor rho2 subunit*ENSMUSG0000002326735
Glra3 / glycine receptor alpha 3 / O75311*ENSMUSG0000003825735
Glra1 / Q64018 / Glycine receptor subunit alpha-1 / P23415* / glycine receptor alpha 1*ENSMUSG0000000026334
Glra2 / Q7TNC8 / Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript variant 3, mRNA. / P23416* / glycine receptor alpha 2*ENSMUSG0000001858934
Gabrr3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) / A8MPY1*ENSMUSG0000007499134
Glrb / P48168 / Glycine receptor subunit beta / P48167* / glycine receptor beta*ENSMUSG0000002802031


Protein motifs (from Interpro)
Interpro ID Name
 IPR002289  Gamma-aminobutyric-acid A receptor, beta subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport ISS
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0021954 central nervous system neuron development IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042698 ovulation cycle IEA
 biological_processGO:0071420 cellular response to histamine IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity ISS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005253 anion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity IEA
 molecular_functionGO:0022851 GABA-gated chloride ion channel activity IEA
 molecular_functionGO:0050811 GABA receptor binding IEA


Pathways (from Reactome)
Pathway description
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Gabrb1m2Qnma/Gabrb1+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Gabrb1m2Qnma/Gabrb1+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0001987 alcohol preference 
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Gabrb1m2Qnma/Gabrb1+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Gabrb1m2Qnma/Gabrb1+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Gabrb1m2Qnma/Gabrb1+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0005130 decreased follicle stimulating hormone level "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0005132 decreased luteinizing hormone level "lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Gabrb1m2Qnma/Gabrb1+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0005138 decreased prolactin level "less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Gabrb1m2Qnma/Gabrb1+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Gabrb1m2Qnma/Gabrb1+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0009751 enhanced behavioral response to alcohol "increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007653 Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*  / complex
 ENSMUSG00000029212 Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*  / complex
 ENSMUSG00000031344 Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*  / complex
 ENSMUSG00000033676 Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*  / complex
 ENSMUSG00000020436 Gabrg2 / P22723 / Gamma-aminobutyric acid receptor subunit gamma-2 / P18507* / gamma-aminobutyric acid type A receptor gamma2 subunit*  / complex
 ENSMUSG00000055026 Gabrg3 / P27681 / Gamma-aminobutyric acid receptor subunit gamma-3 / Q99928* / gamma-aminobutyric acid type A receptor gamma3 subunit*  / complex






 

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