ENSMUSG00000028217


Mus musculus

Features
Gene ID: ENSMUSG00000028217
  
Biological name :Cdh17
  
Synonyms : Cadherin-17 / Cdh17 / Q9R100
  
Possible biological names infered from orthology : Q12864
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 11758147
Gene end: 11817895
  
Corresponding Affymetrix probe sets: 10503341 (MoGene1.0st)   1419331_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029871
Ensembl peptide - ENSMUSP00000103938
NCBI entrez gene - 12557     See in Manteia.
MGI - MGI:1095414
RefSeq - XM_006537584
RefSeq - NM_019753
RefSeq - XM_006537583
RefSeq Peptide - NP_062727
swissprot - Q9R100
swissprot - A2AKS7
Ensembl - ENSMUSG00000028217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh17ENSDARG00000005112Danio rerio
 CDH17ENSGALG00000035094Gallus gallus
 CDH17ENSG00000079112Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdh16 / O88338 / Cadherin-16 / O75309*ENSMUSG0000003188130


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002314 germinal center B cell differentiation IMP
 biological_processGO:0002315 marginal zone B cell differentiation IMP
 biological_processGO:0006857 oligopeptide transport IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0033626 positive regulation of integrin activation by cell surface receptor linked signal transduction IEA
 biological_processGO:0035672 oligopeptide transmembrane transport IEA
 biological_processGO:0048536 spleen development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Syngap1tm1Rlh/Syngap1tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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