ENSMUSG00000029211


Mus musculus

Features
Gene ID: ENSMUSG00000029211
  
Biological name :Gabra4
  
Synonyms : Gabra4 / Gamma-aminobutyric acid receptor subunit alpha-4 / Q9D6F4
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor alpha4 subunit / P48169
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.2
Gene start: 71569749
Gene end: 71658308
  
Corresponding Affymetrix probe sets: 10530421 (MoGene1.0st)   1429330_at (Mouse Genome 430 2.0 Array)   1433707_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143063
Ensembl peptide - ENSMUSP00000143675
Ensembl peptide - ENSMUSP00000031121
Ensembl peptide - ENSMUSP00000142466
NCBI entrez gene - 14397     See in Manteia.
MGI - MGI:95616
RefSeq - NM_010251
RefSeq - XM_006503734
RefSeq - XM_006503735
RefSeq Peptide - NP_034381
swissprot - Q9D6F4
swissprot - Q3USX9
swissprot - A0A0G2JDR1
swissprot - A0A0G2JF83
swissprot - Q543Z0
Ensembl - ENSMUSG00000029211
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabra4ENSDARG00000013389Danio rerio
 GABRA4ENSGALG00000014202Gallus gallus
 GABRA4ENSG00000109158Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabra6 / P16305 / Gamma-aminobutyric acid receptor subunit alpha-6 / Q16445* / gamma-aminobutyric acid type A receptor alpha6 subunit*ENSMUSG0000002042858
Gabra3 / P26049 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 (Gabra3), transcript variant 3, mRNA. / P34903* / gamma-aminobutyric acid type A receptor alpha3 subunit*ENSMUSG0000003134348
Gabra1 / P62812 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 (Gabra1), transcript variant 2, mRNA. / P14867* / gamma-aminobutyric acid type A receptor alpha1 subunit*ENSMUSG0000001080347
Gabra5 / Q8BHJ7 / Gamma-aminobutyric acid receptor subunit alpha-5 / P31644* / gamma-aminobutyric acid type A receptor alpha5 subunit*ENSMUSG0000005507847
Gabra2 / P26048 / Gamma-aminobutyric acid receptor subunit alpha-2 / P47869* / gamma-aminobutyric acid type A receptor alpha2 subunit*ENSMUSG0000000056046
Gabrg1 / Q9R0Y8 / Gamma-aminobutyric acid receptor subunit gamma-1 / Q8N1C3* / gamma-aminobutyric acid type A receptor gamma1 subunit*ENSMUSG0000000126037
Gabrg2 / P22723 / Gamma-aminobutyric acid receptor subunit gamma-2 / P18507* / gamma-aminobutyric acid type A receptor gamma2 subunit*ENSMUSG0000002043637
Gabrg3 / P27681 / Gamma-aminobutyric acid receptor subunit gamma-3 / Q99928* / gamma-aminobutyric acid type A receptor gamma3 subunit*ENSMUSG0000005502635
Gabre / P78334* / gamma-aminobutyric acid type A receptor epsilon subunit*ENSMUSG0000003134028


Protein motifs (from Interpro)
Interpro ID Name
 IPR001390  Gamma-aminobutyric-acid A receptor, alpha subunit
 IPR005434  Gamma-aminobutyric-acid A receptor, alpha 4 subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 biological_processGO:2001023 regulation of response to drug IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA


Pathways (from Reactome)
Pathway description
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm2Osa,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm2Osa,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase2atm1Osa/Dnase2atm2Osa,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Osa/Dnase2atm2Osa,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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