ENSMUSG00000055078


Mus musculus

Features
Gene ID: ENSMUSG00000055078
  
Biological name :Gabra5
  
Synonyms : Gabra5 / Gamma-aminobutyric acid receptor subunit alpha-5 / Q8BHJ7
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor alpha5 subunit / P31644
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B5
Gene start: 57407672
Gene end: 57510059
  
Corresponding Affymetrix probe sets: 10563872 (MoGene1.0st)   1433602_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063276
Ensembl peptide - ENSMUSP00000145685
Ensembl peptide - ENSMUSP00000146238
NCBI entrez gene - 110886     See in Manteia.
MGI - MGI:95617
RefSeq - XM_006540560
RefSeq - NM_176942
RefSeq - XM_006540558
RefSeq - XM_006540559
RefSeq - XM_006540556
RefSeq - XM_006540557
RefSeq Peptide - NP_795916
swissprot - Q8BHJ7
Ensembl - ENSMUSG00000055078
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabra5ENSDARG00000070730Danio rerio
 GABRA5ENSGALG00000016744Gallus gallus
 GABRA5ENSG00000186297Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabra3 / P26049 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 (Gabra3), transcript variant 3, mRNA. / P34903* / gamma-aminobutyric acid type A receptor alpha3 subunit*ENSMUSG0000003134370
Gabra2 / P26048 / Gamma-aminobutyric acid receptor subunit alpha-2 / P47869* / gamma-aminobutyric acid type A receptor alpha2 subunit*ENSMUSG0000000056069
Gabra1 / P62812 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 (Gabra1), transcript variant 2, mRNA. / P14867* / gamma-aminobutyric acid type A receptor alpha1 subunit*ENSMUSG0000001080369
Gabra4 / Q9D6F4 / Gamma-aminobutyric acid receptor subunit alpha-4 / P48169* / gamma-aminobutyric acid type A receptor alpha4 subunit*ENSMUSG0000002921157
Gabra6 / P16305 / Gamma-aminobutyric acid receptor subunit alpha-6 / Q16445* / gamma-aminobutyric acid type A receptor alpha6 subunit*ENSMUSG0000002042855
Gabrg1 / Q9R0Y8 / Gamma-aminobutyric acid receptor subunit gamma-1 / Q8N1C3* / gamma-aminobutyric acid type A receptor gamma1 subunit*ENSMUSG0000000126041
Gabrg2 / P22723 / Gamma-aminobutyric acid receptor subunit gamma-2 / P18507* / gamma-aminobutyric acid type A receptor gamma2 subunit*ENSMUSG0000002043641
Gabrg3 / P27681 / Gamma-aminobutyric acid receptor subunit gamma-3 / Q99928* / gamma-aminobutyric acid type A receptor gamma3 subunit*ENSMUSG0000005502641
Gabre / P78334* / gamma-aminobutyric acid type A receptor epsilon subunit*ENSMUSG0000003134031


Protein motifs (from Interpro)
Interpro ID Name
 IPR001390  Gamma-aminobutyric-acid A receptor, alpha subunit
 IPR005435  Gamma-aminobutyric-acid A receptor, alpha 5 subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0060119 inner ear receptor cell development IMP
 biological_processGO:0060384 innervation IMP
 biological_processGO:0090102 cochlea development IMP
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity IBA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0050811 GABA receptor binding IEA


Pathways (from Reactome)
Pathway description
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004490 type IV spiral ligament fibrocyte degeneration "degeneration or loss of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004632 abnormal cochlear OHC efferent innervation "any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009455 enhanced cued conditioning behavior "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Gabra5tm1Twr/Gabra5tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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