ENSMUSG00000020428


Mus musculus

Features
Gene ID: ENSMUSG00000020428
  
Biological name :Gabra6
  
Synonyms : Gabra6 / Gamma-aminobutyric acid receptor subunit alpha-6 / P16305
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor alpha6 subunit / Q16445
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A5
Gene start: 42306437
Gene end: 42321072
  
Corresponding Affymetrix probe sets: 10385310 (MoGene1.0st)   1417121_at (Mouse Genome 430 2.0 Array)   1451706_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020703
Ensembl peptide - ENSMUSP00000104909
Ensembl peptide - ENSMUSP00000126114
NCBI entrez gene - 14399     See in Manteia.
MGI - MGI:95618
RefSeq - XM_006532198
RefSeq - NM_001099641
RefSeq - NM_008068
RefSeq - XM_006532197
RefSeq Peptide - NP_032094
RefSeq Peptide - NP_001093111
RefSeq Peptide - NP_001345978
swissprot - P16305
Ensembl - ENSMUSG00000020428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabra6aENSDARG00000075058Danio rerio
 gabra6bENSDARG00000058736Danio rerio
 GABRA6ENSGALG00000001695Gallus gallus
 GABRA6ENSG00000145863Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabra4 / Q9D6F4 / Gamma-aminobutyric acid receptor subunit alpha-4 / P48169* / gamma-aminobutyric acid type A receptor alpha4 subunit*ENSMUSG0000002921170
Gabra3 / P26049 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 (Gabra3), transcript variant 3, mRNA. / P34903* / gamma-aminobutyric acid type A receptor alpha3 subunit*ENSMUSG0000003134357
Gabra1 / P62812 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 (Gabra1), transcript variant 2, mRNA. / P14867* / gamma-aminobutyric acid type A receptor alpha1 subunit*ENSMUSG0000001080356
Gabra5 / Q8BHJ7 / Gamma-aminobutyric acid receptor subunit alpha-5 / P31644* / gamma-aminobutyric acid type A receptor alpha5 subunit*ENSMUSG0000005507856
Gabra2 / P26048 / Gamma-aminobutyric acid receptor subunit alpha-2 / P47869* / gamma-aminobutyric acid type A receptor alpha2 subunit*ENSMUSG0000000056055
Gabrg2 / P22723 / Gamma-aminobutyric acid receptor subunit gamma-2 / P18507* / gamma-aminobutyric acid type A receptor gamma2 subunit*ENSMUSG0000002043644
Gabrg3 / P27681 / Gamma-aminobutyric acid receptor subunit gamma-3 / Q99928* / gamma-aminobutyric acid type A receptor gamma3 subunit*ENSMUSG0000005502644
Gabrg1 / Q9R0Y8 / Gamma-aminobutyric acid receptor subunit gamma-1 / Q8N1C3* / gamma-aminobutyric acid type A receptor gamma1 subunit*ENSMUSG0000000126043
Gabre / P78334* / gamma-aminobutyric acid type A receptor epsilon subunit*ENSMUSG0000003134033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001390  Gamma-aminobutyric-acid A receptor, alpha subunit
 IPR005436  Gamma-aminobutyric-acid A receptor, alpha 6 subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity IBA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA


Pathways (from Reactome)
Pathway description
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Xisttm2Nbd/Xist+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0009619 abnormal optokinetic reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement; normally, this reflex functions to stabilize a moving image on the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011039 abnormal vestibuloocular dark reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system when the test is run without light" [MGI:smb]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011040 abnormal vestibuloocular light reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system when the test is run with light" [MGI:smb]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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