ENSMUSG00000030247


Mus musculus

Features
Gene ID: ENSMUSG00000030247
  
Biological name :Kcnj8
  
Synonyms : Kcnj8 / P97794 / potassium inwardly-rectifying channel, subfamily J, member 8
  
Possible biological names infered from orthology : potassium voltage-gated channel subfamily J member 8 / Q15842
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G2
Gene start: 142564837
Gene end: 142571614
  
Corresponding Affymetrix probe sets: 10549102 (MoGene1.0st)   1418142_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032374
Ensembl peptide - ENSMUSP00000145440
NCBI entrez gene - 16523     See in Manteia.
MGI - MGI:1100508
RefSeq - XM_006506915
RefSeq - NM_001330363
RefSeq - NM_008428
RefSeq Peptide - NP_001317292
RefSeq Peptide - NP_032454
swissprot - P97794
swissprot - Q3U118
swissprot - A0A0J9YMM3
Ensembl - ENSMUSG00000030247
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnj8ENSDARG00000045589Danio rerio
 KCNJ8ENSGALG00000026373Gallus gallus
 KCNJ8ENSG00000121361Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnj11 / Q61743 / ATP-sensitive inward rectifier potassium channel 11 / Q14654* / potassium voltage-gated channel subfamily J member 11*ENSMUSG0000009614663
Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*ENSMUSG0000004169542
Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*ENSMUSG0000004252941
Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*ENSMUSG0000004421641
Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*ENSMUSG0000004330140
Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*ENSMUSG0000002682439
Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*ENSMUSG0000003203439
Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*ENSMUSG0000003802638
Kcnj14 / Q8JZN3 / ATP-sensitive inward rectifier potassium channel 14 / Q9UNX9* / potassium voltage-gated channel subfamily J member 14*ENSMUSG0000005874336
Kcnj1 / O88335 / ATP-sensitive inward rectifier potassium channel 1 / P48048* / potassium voltage-gated channel subfamily J member 1*ENSMUSG0000004124835
Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*ENSMUSG0000004470831
Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*ENSMUSG0000006260928


Protein motifs (from Interpro)
Interpro ID Name
 IPR003278  Potassium channel, inwardly rectifying, Kir6.1
 IPR013518  Potassium channel, inwardly rectifying, Kir, cytoplasmic
 IPR014756  Immunoglobulin E-set
 IPR016449  Potassium channel, inwardly rectifying, Kir


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0010107 potassium ion import IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0043330 response to exogenous dsRNA IMP
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential IEA
 biological_processGO:1990573 potassium ion import across plasma membrane IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0008282 inward rectifying potassium channel IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030016 myofibril IDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005242 inward rectifier potassium channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015272 ATP-activated inward rectifier potassium channel activity IEA
 molecular_functionGO:0017098 sulfonylurea receptor binding IEA
 molecular_functionGO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IEA


Pathways (from Reactome)
Pathway description
ATP sensitive Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Kcnj8sltr/Kcnj8sltr
Genetic Background: involves: C57BL/6J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Kcnj8sos/Kcnj8sos
Genetic Background: C57BL/6J-Kcnj8sos

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj8sltr/Kcnj8sltr
Genetic Background: involves: C57BL/6J

Allelic Composition: Kcnj8gnite/Kcnj8gnite
Genetic Background: involves: C57BL/6J

Allelic Composition: Kcnj8slmbr/Kcnj8slmbr
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030247 Kcnj8 / P97794 / potassium inwardly-rectifying channel, subfamily J, member 8 / Q15842* / potassium voltage-gated channel subfamily J member 8*  / complex
 ENSMUSG00000030249 Abcc9 / P70170 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / O60706* / ATP binding cassette subfamily C member 9*  / complex
 ENSMUSG00000096146 Kcnj11 / Q61743 / ATP-sensitive inward rectifier potassium channel 11 / Q14654* / potassium voltage-gated channel subfamily J member 11*  / complex






 

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