ENSMUSG00000030249


Mus musculus

Features
Gene ID: ENSMUSG00000030249
  
Biological name :Abcc9
  
Synonyms : Abcc9 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / P70170
  
Possible biological names infered from orthology : ATP binding cassette subfamily C member 9 / O60706
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G2
Gene start: 142587862
Gene end: 142702315
  
Corresponding Affymetrix probe sets: 10549108 (MoGene1.0st)   1420408_a_at (Mouse Genome 430 2.0 Array)   1435751_at (Mouse Genome 430 2.0 Array)   1435752_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144779
Ensembl peptide - ENSMUSP00000107401
Ensembl peptide - ENSMUSP00000145489
Ensembl peptide - ENSMUSP00000072914
Ensembl peptide - ENSMUSP00000084805
Ensembl peptide - ENSMUSP00000098390
NCBI entrez gene - 20928     See in Manteia.
MGI - MGI:1352630
RefSeq - XM_006506952
RefSeq - NM_001310143
RefSeq - NM_011511
RefSeq - NM_021041
RefSeq - NM_021042
RefSeq - XM_006506948
RefSeq - XM_006506949
RefSeq - XM_006506950
RefSeq - XM_006506951
RefSeq - NM_001044720
RefSeq Peptide - NP_066378
RefSeq Peptide - NP_001038185
RefSeq Peptide - NP_001297072
RefSeq Peptide - NP_066379
RefSeq Peptide - NP_035641
swissprot - P70170
swissprot - E9PUE8
swissprot - A0A0N4SWE6
Ensembl - ENSMUSG00000030249
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcc9ENSDARG00000015985Danio rerio
 ABCC9ENSGALG00000013244Gallus gallus
 ABCC9ENSG00000069431Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcc3 / ATP binding cassette subfamily C member 3 / O15438*ENSMUSG0000002086532
Abcc1 / O35379 / ATP-binding cassette, sub-family C (CFTR/MRP), member 1 / P33527* / ATP binding cassette subfamily C member 1*ENSMUSG0000002308831
Abcc2 / Q8VI47 / Canalicular multispecific organic anion transporter 1 / Q92887* / ATP binding cassette subfamily C member 2*ENSMUSG0000002519430
Abcc5 / Q9R1X5 / Multidrug resistance-associated protein 5 / O15440* / ATP binding cassette subfamily C member 5*ENSMUSG0000002282227
Abcc4 / ATP-binding cassette, sub-family C (CFTR/MRP), member 4 / O15439* / ATP binding cassette subfamily C member 4*ENSMUSG0000003284926
Abcc12 / Q80WJ6 / Multidrug resistance-associated protein 9 / Q96J65* / ATP binding cassette subfamily C member 12*ENSMUSG0000003687225
Cftr / P26361 / Cystic fibrosis transmembrane conductance regulator / P13569*ENSMUSG0000004130122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000388  Sulphonylurea receptor
 IPR001475  ATP-binding cassette subfamily C member 9
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0042493 response to drug IBA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IBA
 cellular_componentGO:0008282 inward rectifying potassium channel IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030017 sarcomere IDA
 cellular_componentGO:0042383 sarcolemma IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005267 potassium channel activity IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008281 sulfonylurea receptor activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0044325 ion channel binding ISO


Pathways (from Reactome)
Pathway description
ATP sensitive Potassium channels
ABC-family proteins mediated transport
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic Background: Not Specified

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic Background: Not Specified

 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic Background: Not Specified

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic Background: Not Specified

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003897 abnormal ST interval "anomaly in the time between the end of S-wave and the beginning of T-wave" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic Background: Not Specified

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic Background: Not Specified

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0006135 arterial stenosis "abnormal narrowing of the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic Background: Not Specified

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic Background: Not Specified

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic Background: Not Specified

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011390 abnormal fetal cardiomyocyte physiology "any functional anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [MGI:csmith, PMID:17429040]
Show

Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011631 decreased mitochondria size "reduced size of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0014172 decreased fatty acid oxidation 
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030247 Kcnj8 / P97794 / potassium inwardly-rectifying channel, subfamily J, member 8 / Q15842* / potassium voltage-gated channel subfamily J member 8*  / complex
 ENSMUSG00000030249 Abcc9 / P70170 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / O60706* / ATP binding cassette subfamily C member 9*  / complex
 ENSMUSG00000096146 Kcnj11 / Q61743 / ATP-sensitive inward rectifier potassium channel 11 / Q14654* / potassium voltage-gated channel subfamily J member 11*  / complex






 

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