MP:0000189 | hypoglycemia | "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0000230 | abnormal blood pressure | "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb Genetic Background: Not Specified
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MP:0000231 | hypertension | "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb Genetic Background: Not Specified
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MP:0000250 | abnormal vasoconstriction | "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb Genetic Background: Not Specified
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MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb Genetic Background: Not Specified
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MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0002891 | increased insulin sensitivity | "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission] |
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0003897 | abnormal ST interval | "anomaly in the time between the end of S-wave and the beginning of T-wave" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb Genetic Background: Not Specified
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MP:0005039 | hypoxia | "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0005290 | decreased oxygen consumption | "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0005330 | cardiomyopathy | "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0005595 | abnormal vascular smooth muscle physiology | "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb Genetic Background: Not Specified
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MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0006135 | arterial stenosis | "abnormal narrowing of the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb Genetic Background: Not Specified
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MP:0006143 | increased diastolic blood pressure | "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb Genetic Background: Not Specified
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MP:0006144 | increased systolic blood pressure | "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Abcc9tm1Cfb/Abcc9tm1Cfb Genetic Background: Not Specified
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MP:0008406 | increased cellular sensitivity to hydrogen peroxide | "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0008788 | abnormal fetal cardiomyocyte morphology | "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0011390 | abnormal fetal cardiomyocyte physiology | "any functional anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [MGI:csmith, PMID:17429040] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0011631 | decreased mitochondria size | "reduced size of the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0014172 | decreased fatty acid oxidation | |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0030021 | increased muscle cell glucose uptake | "increased ability of muscle cells to take in glucose" [MGI:anna] |
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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