ENSMUSG00000030762


Mus musculus

Features
Gene ID: ENSMUSG00000030762
  
Biological name :Aqp8
  
Synonyms : Aqp8 / Aquaporin-8 / P56404
  
Possible biological names infered from orthology : O94778
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 123462291
Gene end: 123468004
  
Corresponding Affymetrix probe sets: 10557300 (MoGene1.0st)   1417828_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033023
Ensembl peptide - ENSMUSP00000095664
NCBI entrez gene - 11833     See in Manteia.
MGI - MGI:1195271
RefSeq - NM_001109045
RefSeq - NM_007474
RefSeq Peptide - NP_001102515
RefSeq Peptide - NP_031500
swissprot - P56404
swissprot - A0A0X1KG59
Ensembl - ENSMUSG00000030762
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aqp8a.1ENSDARG00000045141Danio rerio
 AQP8ENSG00000103375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aqp4 / aquaporin-4 isoform M1x / P55087* / aquaporin 4*ENSMUSG0000002441128
Aqp2 / P56402 / Aquaporin-2 / P41181*ENSMUSG0000002301327
Mip / P51180 / Lens fiber major intrinsic protein / P30301* / major intrinsic protein of lens fiber*ENSMUSG0000002538927
Aqp6 / Q8C4A0 / Aquaporin-6 / Q13520*ENSMUSG0000004314426
Aqp5 / Q9WTY4 / Aquaporin-5 / P55064*ENSMUSG0000004421726
Aqp1 / Q02013 / Aquaporin-1 / P29972* / AC004691.2* / aquaporin 1 (Colton blood group)*ENSMUSG0000000465523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000425  Major intrinsic protein
 IPR022357  Major intrinsic protein, conserved site
 IPR023271  Aquaporin-like
 IPR023277  Aquaporin 8
 IPR034294  Aquaporin transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006833 water transport IMP
 biological_processGO:0034220 ion transmembrane transport IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0015250 water channel activity TAS
 molecular_functionGO:0015267 channel activity IEA


Pathways (from Reactome)
Pathway description
Passive transport by Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax67Neu/Pax6+
Genetic Background: involves: 102 * C3H

 MP:0001148 enlarged testes "increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Adora3tm1(ADORA3)Msth/Adora3tm1(ADORA3)Msth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Adora3tm1(ADORA3)Msth/Adora3tm1(ADORA3)Msth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Adora3tm1(ADORA3)Msth/Adora3tm1(ADORA3)Msth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adora3tm1(ADORA3)Msth/Adora3tm1(ADORA3)Msth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp8tm1Ask/Aqp8tm1Ask
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adora3tm1(ADORA3)Msth/Adora3tm1(ADORA3)Msth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adora3tm1(ADORA3)Msth/Adora3tm1(ADORA3)Msth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030762 Aqp8 / P56404 / Aquaporin-8 / O94778*  / complex






 

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