ENSMUSG00000025389


Mus musculus

Features
Gene ID: ENSMUSG00000025389
  
Biological name :Mip
  
Synonyms : Lens fiber major intrinsic protein / Mip / P51180
  
Possible biological names infered from orthology : major intrinsic protein of lens fiber / P30301
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128225838
Gene end: 128231812
  
Corresponding Affymetrix probe sets: 10367173 (MoGene1.0st)   1421039_at (Mouse Genome 430 2.0 Array)   1435447_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026455
NCBI entrez gene - 17339     See in Manteia.
MGI - MGI:96990
RefSeq - NM_008600
RefSeq Peptide - NP_032626
swissprot - P51180
Ensembl - ENSMUSG00000025389
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mipaENSDARG00000037285Danio rerio
 mipbENSDARG00000013963Danio rerio
 MIPENSGALG00000042119Gallus gallus
 MIPENSG00000135517Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aqp2 / P56402 / Aquaporin-2 / P41181*ENSMUSG0000002301359
Aqp6 / Q8C4A0 / Aquaporin-6 / Q13520*ENSMUSG0000004314450
Aqp5 / Q9WTY4 / Aquaporin-5 / P55064*ENSMUSG0000004421749
Aqp1 / Q02013 / Aquaporin-1 / P29972* / AC004691.2* / aquaporin 1 (Colton blood group)*ENSMUSG0000000465546
Aqp4 / aquaporin-4 isoform M1x / P55087* / aquaporin 4*ENSMUSG0000002441143
Aqp8 / P56404 / Aquaporin-8 / O94778*ENSMUSG0000003076227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000425  Major intrinsic protein
 IPR022357  Major intrinsic protein, conserved site
 IPR023271  Aquaporin-like
 IPR034294  Aquaporin transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0006833 water transport IMP
 biological_processGO:0007154 cell communication NAS
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0034220 ion transmembrane transport IBA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1990349 gap junction-mediated intercellular transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0016324 apical plasma membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005212 structural constituent of eye lens IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISS
 molecular_functionGO:0015250 water channel activity IEA
 molecular_functionGO:0015267 channel activity NAS


Pathways (from Reactome)
Pathway description
Passive transport by Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: MipCat-Lop/MipCat-Lop
Genetic Background: involves: STOCK Rb(6.15)1Ald

Allelic Composition: MipCat-Lop/Mip+
Genetic Background: involves: STOCK Rb(6.15)1Ald

Allelic Composition: MipCat-Tohm/MipCat-Tohm
Genetic Background: DDI

Allelic Composition: MipCts/MipCts
Genetic Background: involves: Jcl:ICR

Allelic Composition: MipCts/MipCts
Genetic Background: CTA/Idr

Allelic Composition: MipCts/MipCts
Genetic Background: CTS/Shi

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Mgat1tm1Pst/Mgat1tm1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1 * SJL

Allelic Composition: MipCat-Lop/MipCat-Lop
Genetic Background: involves: STOCK Rb(6.15)1Ald

Allelic Composition: MipCat-Tohm/MipCat-Tohm
Genetic Background: DDI

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

Allelic Composition: MipGt(OST1231)Lex/MipGt(OST1231)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: MipCts/Mip+
Genetic Background: involves: Jcl:ICR

Allelic Composition: MipCts/MipCts
Genetic Background: involves: Jcl:ICR

Allelic Composition: MipCts/MipCts
Genetic Background: CTA/Idr

Allelic Composition: MipCts/Mip+
Genetic Background: (CTS x KYF/MsIdr)F1

Allelic Composition: MipCts/Mip+
Genetic Background: (CTA/Idr x KYF/MsIdr)F1

Allelic Composition: MipCts/Mip+
Genetic Background: (CTA/Idr x C57BL/6J)F1

Allelic Composition: MipCts/Mip+
Genetic Background: (CTA/Idr x ICR/Jcl)F1

Allelic Composition: MipCts/Mip+
Genetic Background: (CTA/Idr x MT/HokIdr)F1

Allelic Composition: MipCts/Mip+
Genetic Background: (CTS/Shi x C57BL/6J)F1

Allelic Composition: MipCts/MipCts
Genetic Background: CTS/Shi

Allelic Composition: MipCts/Mip+
Genetic Background: involves: C57BL/6J * CTS/Shi

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Mgat1tm1Pst/Mgat1tm1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1 * SJL

Allelic Composition: MipCat-Lop/MipCat-Lop
Genetic Background: involves: STOCK Rb(6.15)1Ald

 MP:0001309 hydropic eye lens fibers "swollen cortical fibers of the eye lens" [J:14285]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: MipCts/MipCts
Genetic Background: CTA/Idr

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mgat1tm1Pst/Mgat1tm1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1 * SJL

Allelic Composition: MipCat-Lop/MipCat-Lop
Genetic Background: involves: STOCK Rb(6.15)1Ald

Allelic Composition: MipCat-Tohm/MipCat-Tohm
Genetic Background: DDI

Allelic Composition: MipCts/MipCts
Genetic Background: CTA/Idr

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: MipCat-Tohm/MipCat-Tohm
Genetic Background: DDI

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: MipGt(OST1231)Lex/MipGt(OST1231)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MipCts/Mip+
Genetic Background: (CTS/Shi x C57BL/6J)F1

Allelic Composition: MipCts/MipCts
Genetic Background: CTS/Shi

Allelic Composition: MipCts/Mip+
Genetic Background: involves: C57BL/6J * CTS/Shi

 MP:0010263 total cataracts "a lens opacity which involves both nuclear and cortical regions, including all fibers of a lens; usually congenital" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: MipCat-Lop/Mip+
Genetic Background: involves: STOCK Rb(6.15)1Ald

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
Show

Allelic Composition: MipCts/MipCts
Genetic Background: CTS/Shi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025389 Mip / P51180 / Lens fiber major intrinsic protein / P30301* / major intrinsic protein of lens fiber*  / complex






 

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