ENSMUSG00000030798


Mus musculus

Features
Gene ID: ENSMUSG00000030798
  
Biological name :Cd37
  
Synonyms : Cd37 / Leukocyte antigen CD37 / Q61470
  
Possible biological names infered from orthology : CD37 molecule / P11049
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45233632
Gene end: 45239115
  
Corresponding Affymetrix probe sets: 10563178 (MoGene1.0st)   1419206_at (Mouse Genome 430 2.0 Array)   1425736_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147416
Ensembl peptide - ENSMUSP00000147818
Ensembl peptide - ENSMUSP00000148136
Ensembl peptide - ENSMUSP00000148065
Ensembl peptide - ENSMUSP00000148047
Ensembl peptide - ENSMUSP00000033063
Ensembl peptide - ENSMUSP00000096061
NCBI entrez gene - 12493     See in Manteia.
MGI - MGI:88330
RefSeq - NM_001290804
RefSeq - XM_006540593
RefSeq - XM_006540592
RefSeq - NM_007645
RefSeq - NM_001290802
RefSeq Peptide - NP_001277733
RefSeq Peptide - NP_001277731
RefSeq Peptide - NP_031671
swissprot - A0A1B0GSZ7
swissprot - A0A1B0GST6
swissprot - Q3U1W9
swissprot - Q3U429
swissprot - Q4FK35
swissprot - Q61470
swissprot - A0A1B0GS72
swissprot - A0A1B0GSS0
Ensembl - ENSMUSG00000030798
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD37ENSG00000104894Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd82 / P40237 / CD82 antigen / P27701* / CD82 molecule*ENSMUSG0000002721533
Q9DCK3 / Tspan4 / tetraspanin 4 / O14817*ENSMUSG0000002551121
Q80WR1 / Tspan18 / Tetraspanin-18 / Q96SJ8*ENSMUSG0000002721720
Q99J59 / Tspan1 / Tetraspanin-1 / O60635*ENSMUSG0000002869920
Q8BJU2 / Tspan9 / Mus musculus tetraspanin 9 (Tspan9), transcript variant 2, mRNA. / O75954* / tetraspanin 9*ENSMUSG0000003035220
Q8R3G9 / Tspan8 / Tetraspanin-8 / P19075*ENSMUSG0000003412720
Cd53 / Q61451 / Leukocyte surface antigen CD53 / P19397* / CD53 molecule*ENSMUSG0000004074720
Cd9 / P40240 / CD9 antigen / P21926* / CD9 molecule*ENSMUSG0000003034219
Q922J6 / Tspan2 / tetraspanin 2 / O60636*ENSMUSG0000002785817
Cd81 / P35762 / CD81 antigen / P60033* / CD81 molecule*ENSMUSG0000003770617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000301  Tetraspanin
 IPR008952  Tetraspanin, EC2 domain superfamily
 IPR018499  Tetraspanin/Peripherin
 IPR018503  Tetraspanin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002639 positive regulation of immunoglobulin production IMP
 biological_processGO:0002920 regulation of humoral immune response IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0030886 negative regulation of myeloid dendritic cell activation IGI
 biological_processGO:0042832 defense response to protozoan IGI
 biological_processGO:0050688 regulation of defense response to virus IGI
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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