ENSMUSG00000031355


Mus musculus

Features
Gene ID: ENSMUSG00000031355
  
Biological name :Arhgap6
  
Synonyms : Arhgap6 / O54834 / Rho GTPase activating protein 6
  
Possible biological names infered from orthology : O43182
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F5
Gene start: 168795099
Gene end: 169304435
  
Corresponding Affymetrix probe sets: 10603182 (MoGene1.0st)   1417704_a_at (Mouse Genome 430 2.0 Array)   1451867_x_at (Mouse Genome 430 2.0 Array)   1456333_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033721
Ensembl peptide - ENSMUSP00000107757
Ensembl peptide - ENSMUSP00000134512
Ensembl peptide - ENSMUSP00000107759
Ensembl peptide - ENSMUSP00000084239
Ensembl peptide - ENSMUSP00000107755
NCBI entrez gene - 11856     See in Manteia.
MGI - MGI:1196332
RefSeq - NM_178754
RefSeq - XM_011247783
RefSeq - XM_006528694
RefSeq - NM_001287530
RefSeq - NM_009707
RefSeq Peptide - NP_001274459
RefSeq Peptide - NP_033837
RefSeq Peptide - NP_848869
swissprot - G3UZI7
swissprot - O54834
swissprot - A2ALX7
swissprot - A2ALX6
Ensembl - ENSMUSG00000031355
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGAP6ENSGALG00000016602Gallus gallus
 O43182ENSG00000047648Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B1AUC7 / Arhgap36 / Mus musculus Rho GTPase activating protein 36 (Arhgap36), transcript variant 2, mRNA. / Q6ZRI8* / Rho GTPase activating protein 36*ENSMUSG0000003619818
Q923Q2 / Stard13 / StAR-related lipid transfer protein 13 / Q9Y3M8* / StAR related lipid transfer domain containing 13*ENSMUSG0000001612815
Q80Y19 / Arhgap11a / Rho GTPase-activating protein 11A / Q6P4F7*ENSMUSG0000004121914
Q8K031 / Stard8 / StAR-related lipid transfer protein 8 / Q92502* / StAR related lipid transfer domain containing 8*ENSMUSG0000003121613
Dlc1 / DLC1 Rho GTPase activating protein / Q96QB1*ENSMUSG0000003152313
Q8BN58 / Arhgap28 / Mus musculus Rho GTPase activating protein 28 (Arhgap28), transcript variant 2, mRNA. / Q9P2N2* / Rho GTPase activating protein 28*ENSMUSG0000002404312
Q8K0Q5 / Arhgap18 / Rho GTPase-activating protein 18 / Q8N392*ENSMUSG0000003903112
E9Q6X9 / Arhgap40 / Rho GTPase-activating protein 40 / Q5TG30*ENSMUSG0000007462511
Gm42906ENSMUSG000001070111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR008936  Rho GTPase activation protein
 IPR030772  Rho GTPase-activating protein 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007202 activation of phospholipase C activity ISO
 biological_processGO:0010518 positive regulation of phospholipase activity ISO
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0048041 focal adhesion assembly IDA
 biological_processGO:0051497 negative regulation of stress fiber assembly ISO
 biological_processGO:0051895 negative regulation of focal adhesion assembly ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0016004 phospholipase activator activity ISO
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0043274 phospholipase binding ISO


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6/Hccs/Mid1tm1Hzo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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