Manteia

ENSMUSG00000031492

Mus musculus

Features

Gene ID:	ENSMUSG00000031492

Biological name :	Chrnb3

Synonyms :	cholinergic receptor, nicotinic, beta polypeptide 3 / Chrnb3 / Q8BMN3

Possible biological names infered from orthology :	cholinergic receptor nicotinic beta 3 subunit / Q05901

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	A2
Gene start:	27368711
Gene end:	27399730

Corresponding Affymetrix probe sets:	10571170 (MoGene1.0st) 1451842_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000052297 Ensembl peptide - ENSMUSP00000078428 Ensembl peptide - ENSMUSP00000147672 NCBI entrez gene - 108043 See in Manteia. MGI - MGI:106212 RefSeq - NM_027454 RefSeq - NM_173212 RefSeq Peptide - NP_081730 RefSeq Peptide - NP_775304 swissprot - Q3UZS0 swissprot - Q8BMN3 Ensembl - ENSMUSG00000031492

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*	ENSMUSG00000035594	62
Chrna2 / Q91X60 / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Q15822* / cholinergic receptor nicotinic alpha 2 subunit*	ENSMUSG00000022041	51
Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*	ENSMUSG00000027577	50
Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*	ENSMUSG00000032303	47
Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*	ENSMUSG00000031491	46
Chrna1 / P04756 / cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) / P02708* / cholinergic receptor nicotinic alpha 1 subunit*	ENSMUSG00000027107	41
Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*	ENSMUSG00000035200	41
Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*	ENSMUSG00000027950	39

Protein motifs (from Interpro)

Interpro ID	Name
IPR002394	Nicotinic acetylcholine receptor
IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
IPR006201	Neurotransmitter-gated ion-channel
IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
IPR018000	Neurotransmitter-gated ion-channel, conserved site
IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily
IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007271	synaptic transmission, cholinergic	IBA
biological_process	GO:0007274	neuromuscular synaptic transmission	IBA
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0035094	response to nicotine	IBA
biological_process	GO:0051291	protein heterooligomerization	IEA
biological_process	GO:0060078	regulation of postsynaptic membrane potential	IEA
biological_process	GO:0060079	excitatory postsynaptic potential	IEA
biological_process	GO:0098655	cation transmembrane transport	IBA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005892	acetylcholine-gated channel complex	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0043005	neuron projection	IEA
cellular_component	GO:0045202	synapse	IEA
cellular_component	GO:0045211	postsynaptic membrane	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005230	extracellular ligand-gated ion channel activity	IEA
molecular_function	GO:0008144	drug binding	IEA
molecular_function	GO:0022848	acetylcholine-gated cation-selective channel activity	IBA
molecular_function	GO:0042166	acetylcholine binding	IBA

Pathways (from Reactome)

Pathway description

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Trp53^tm2Glo/Trp53^tm2Glo Genetic Background: involves: 129/Sv * C57BL/6
MP:0001486	abnormal startle reflex	"abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Trp53^tm2Glo/Trp53^tm2Glo Genetic Background: involves: 129/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000031491	Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*	/ complex
ENSMUSG00000035200	Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*	/ complex
ENSMUSG00000027577	Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*	/ complex
ENSMUSG00000022041	Chrna2 / Q91X60 / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Q15822* / cholinergic receptor nicotinic alpha 2 subunit*	/ complex
ENSMUSG00000031492	Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr