Manteia

ENSMUSG00000022041

Mus musculus

Features

Gene ID:	ENSMUSG00000022041

Biological name :	Chrna2

Synonyms :	cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Chrna2 / Q91X60

Possible biological names infered from orthology :	cholinergic receptor nicotinic alpha 2 subunit / Q15822

Species:	Mus musculus

Chr. number:	14
Strand:	1
Band:	D1
Gene start:	66135039
Gene end:	66152948

Corresponding Affymetrix probe sets:	10416071 (MoGene1.0st) 1425409_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000022620 Ensembl peptide - ENSMUSP00000145896 NCBI entrez gene - 110902 See in Manteia. MGI - MGI:87886 RefSeq - XM_006518436 RefSeq - NM_144803 RefSeq - XM_006518434 RefSeq - XM_006518435 RefSeq Peptide - NP_659052 swissprot - Q91X60 Ensembl - ENSMUSG00000022041

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
chrna2a	ENSDARG00000006602	Danio rerio
chrna2b	ENSDARG00000057025	Danio rerio
CHRNA2	ENSGALG00000016565	Gallus gallus
CHRNA2	ENSG00000120903	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*	ENSMUSG00000027577	65
Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*	ENSMUSG00000032303	54
Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*	ENSMUSG00000031491	50
Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*	ENSMUSG00000027950	46
Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*	ENSMUSG00000031492	46
Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*	ENSMUSG00000035200	44
Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*	ENSMUSG00000035594	44
Chrna1 / P04756 / cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) / P02708* / cholinergic receptor nicotinic alpha 1 subunit*	ENSMUSG00000027107	42

Protein motifs (from Interpro)

Interpro ID	Name
IPR002394	Nicotinic acetylcholine receptor
IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
IPR006201	Neurotransmitter-gated ion-channel
IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
IPR018000	Neurotransmitter-gated ion-channel, conserved site
IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily
IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007271	synaptic transmission, cholinergic	IBA
biological_process	GO:0007274	neuromuscular synaptic transmission	IBA
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0035094	response to nicotine	IBA
biological_process	GO:0051291	protein heterooligomerization	IEA
biological_process	GO:0060078	regulation of postsynaptic membrane potential	IEA
biological_process	GO:0060079	excitatory postsynaptic potential	IEA
biological_process	GO:0098655	cation transmembrane transport	IBA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005892	acetylcholine-gated channel complex	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0045202	synapse	IEA
cellular_component	GO:0045211	postsynaptic membrane	IEA
cellular_component	GO:0071944	cell periphery	IDA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005230	extracellular ligand-gated ion channel activity	IEA
molecular_function	GO:0008144	drug binding	IEA
molecular_function	GO:0015464	acetylcholine receptor activity	IEA
molecular_function	GO:0022848	acetylcholine-gated cation-selective channel activity	IBA
molecular_function	GO:0042166	acetylcholine binding	IEA

Pathways (from Reactome)

Pathway description

Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Highly calcium permeable nicotinic acetylcholine receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ccl11^tm1Mer/Ccl11^tm1Mer,Ccl24^tm1Mer/Ccl24^tm1Mer Genetic Background: 129S.129S6(Cg)-Ccl24^tm1Mer Ccl11^tm1Mer
MP:0002207	abnormal long term potentiation	"alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lrp2^tm1Her/Lrp2^tm1Her Genetic Background: involves: 129S7/SvEvBrd
MP:0002910	abnormal excitatory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Lrp2^tm1Her/Lrp2^tm1Her Genetic Background: involves: 129S7/SvEvBrd
MP:0002945	abnormal inhibitory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Lrp2^tm1Her/Lrp2^tm1Her Genetic Background: involves: 129S7/SvEvBrd
MP:0008874	decreased sensitivity to xenobiotics	"increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp2^tm1Her/Lrp2^tm1Her Genetic Background: involves: 129S7/SvEvBrd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000022041	Chrna2 / Q91X60 / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Q15822* / cholinergic receptor nicotinic alpha 2 subunit*	/ complex
ENSMUSG00000031492	Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr