ENSMUSG00000032006


Mus musculus

Features
Gene ID: ENSMUSG00000032006
  
Biological name :Pdgfd
  
Synonyms : Mus musculus platelet-derived growth factor, D polypeptide (Pdgfd), transcript variant 2, mRNA. / Pdgfd / Q925I7
  
Possible biological names infered from orthology : platelet derived growth factor D / Q9GZP0
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 6168584
Gene end: 6378850
  
Corresponding Affymetrix probe sets: 10583021 (MoGene1.0st)   1426319_at (Mouse Genome 430 2.0 Array)   1446691_at (Mouse Genome 430 2.0 Array)   1456532_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056240
Ensembl peptide - ENSMUSP00000128388
Ensembl peptide - ENSMUSP00000149162
NCBI entrez gene - 71785     See in Manteia.
MGI - MGI:1919035
RefSeq - XM_011242370
RefSeq - NM_001357397
RefSeq - NM_001357398
RefSeq - NM_027924
RefSeq - XM_006509885
RefSeq - XM_006509886
RefSeq - XM_006509887
RefSeq Peptide - NP_001344326
RefSeq Peptide - NP_001344327
RefSeq Peptide - NP_082200
swissprot - Q925I7
Ensembl - ENSMUSG00000032006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfdENSDARG00000077677Danio rerio
 PDGFDENSGALG00000017179Gallus gallus
 PDGFDENSG00000170962Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdgfc / Q8CI19 / platelet-derived growth factor, C polypeptide / Q9NRA1* / platelet derived growth factor C*ENSMUSG0000002801940


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR000859  CUB domain
 IPR027123  Platelet-derived growth factor D
 IPR029034  Cystine-knot cytokine
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007596 blood coagulation IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0009987 cellular process ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0030335 positive regulation of cell migration IBA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IBA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IBA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IBA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071673 positive regulation of smooth muscle cell chemotaxis IEA
 biological_processGO:0072126 positive regulation of glomerular mesangial cell proliferation IEA
 biological_processGO:2000439 positive regulation of monocyte extravasation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by PDGF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction
 ENSMUSG00000031538 Plat / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B / P00750* / plasminogen activator, tissue type*  / reaction
 ENSMUSG00000032006 Pdgfd / Q925I7 / Mus musculus platelet-derived growth factor, D polypeptide (Pdgfd), transcript variant 2, mRNA. / Q9GZP0* / platelet derived growth factor D*  / complex






 

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