ENSMUSG00000032310


Mus musculus

Features
Gene ID: ENSMUSG00000032310
  
Biological name :Cyp1a2
  
Synonyms : Cyp1a2 / Cytochrome P450 1A2 / P00186
  
Possible biological names infered from orthology : cytochrome P450 family 1 subfamily A member 2 / P05177
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 57676937
Gene end: 57683703
  
Corresponding Affymetrix probe sets: 10593981 (MoGene1.0st)   1450715_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034860
NCBI entrez gene - 13077     See in Manteia.
MGI - MGI:88589
RefSeq - NM_009993
RefSeq Peptide - NP_034123
swissprot - B6VGH4
swissprot - P00186
Ensembl - ENSMUSG00000032310
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp1aENSDARG00000098315Danio rerio
 CYP1A1ENSGALG00000001325Gallus gallus
 CYP1A2ENSGALG00000001320Gallus gallus
 CYP1A2ENSG00000140505Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp1a1 / P00184 / Cytochrome P450 1A1 / P04798* / cytochrome P450 family 1 subfamily A member 1*ENSMUSG0000003231571
Cyp1b1 / Q64429 / Cytochrome P450 1B1 / Q16678* / cytochrome P450 family 1 subfamily B member 1*ENSMUSG0000002408737
P27786 / Cyp17a1 / Steroid 17-alpha-hydroxylase/17,20 lyase / P05093* / cytochrome P450 family 17 subfamily A member 1*ENSMUSG0000000355528
Cyp2s1 / Q9DBX6 / Cytochrome P450 2S1 / Q96SQ9* / cytochrome P450 family 2 subfamily S member 1*ENSMUSG0000004070327
Cyp2c68 / cytochrome P450, family 2, subfamily c, polypeptide 68ENSMUSG0000007488226
Cyp2t4 / cytochrome P450, family 2, subfamily t, polypeptide 4ENSMUSG0000007878726
Cyp2c67 / cytochrome P450, family 2, subfamily c, polypeptide 67ENSMUSG0000006262425
Cyp21a1 / P08686* / CYP21A2* / cytochrome P450 family 21 subfamily A member 2*ENSMUSG0000002436524
Cyp2ab1 / cytochrome P450, family 2, subfamily ab, polypeptide 1ENSMUSG0000002281814


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008066  Cytochrome P450, E-class, group I, CYP1
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006706 steroid catabolic process IEA
 biological_processGO:0006725 cellular aromatic compound metabolic process IMP
 biological_processGO:0006778 porphyrin-containing compound metabolic process IMP
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0009403 toxin biosynthetic process ISO
 biological_processGO:0009404 toxin metabolic process IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0009820 alkaloid metabolic process ISO
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016098 monoterpenoid metabolic process ISO
 biological_processGO:0017144 drug metabolic process ISO
 biological_processGO:0018894 dibenzo-p-dioxin metabolic process IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032787 monocarboxylic acid metabolic process ISO
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042737 drug catabolic process ISO
 biological_processGO:0042738 exogenous drug catabolic process ISO
 biological_processGO:0045333 cellular respiration IMP
 biological_processGO:0046483 heterocycle metabolic process ISO
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IMP
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0070989 oxidative demethylation ISO
 biological_processGO:0071276 cellular response to cadmium ion IDA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0071615 oxidative deethylation ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 molecular_functionGO:0004497 monooxygenase activity ISO
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity ISO
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen ISO
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0020037 heme binding ISO
 molecular_functionGO:0032451 demethylase activity ISO
 molecular_functionGO:0034875 caffeine oxidase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA


Pathways (from Reactome)
Pathway description
Methylation
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Aflatoxin activation and detoxification
Biosynthesis of protectins
Biosynthesis of maresin-like SPMs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0002271 abnormal alveolar duct morphology "any structural anomaly of the conducting tubes leading to the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyp1a2/Cyp1a1tm1.1Bra/Cyp1a2/Cyp1a1tm1.1Bra
Genetic Background: B6.129-Cyp1a2/Cyp1a1tm1.1Bra

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

Allelic Composition: Cyp1a2tm1Dwn/Cyp1a2tm1Dwn
Genetic Background: B6.129P2-Cyp1a2tm1Dwn

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp1a2tm1Dwn/Cyp1a2tm1Dwn
Genetic Background: B6.129P2-Cyp1a2tm1Dwn

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp1a2tm1Dwn/Cyp1a2tm1Dwn
Genetic Background: B6.129P2-Cyp1a2tm1Dwn

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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