ENSDARG00000098315


Danio rerio

Features
Gene ID: ENSDARG00000098315
  
Biological name :cyp1a
  
Synonyms : cyp1a / cytochrome P450, family 1, subfamily A
  
Possible biological names infered from orthology : CYP1A1 / CYP1A2 / Cytochrome P450 1A1 / Cytochrome P450 1A2 / cytochrome P450 family 1 subfamily A member 1 / cytochrome P450 family 1 subfamily A member 2 / P00184 / P00186 / P04798 / P05177
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 5588068
Gene end: 5598958
  
Corresponding Affymetrix probe sets: Dr.9478.1.S1_at (Zebrafish Array)   NM_131879_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000139599
Ensembl peptide - ENSDARP00000151321
NCBI entrez gene - 140634     See in Manteia.
RefSeq - NM_131879
RefSeq Peptide - NP_571954
swissprot - Q8UW07
ZFIN ID - ZDB-GENE-011219-1
Ensembl - ENSDARG00000098315
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP1A1ENSGALG00000001325Gallus gallus
 CYP1A2ENSGALG00000001320Gallus gallus
 CYP1A1ENSG00000140465Homo sapiens
 CYP1A2ENSG00000140505Homo sapiens
 Cyp1a1ENSMUSG00000032315Mus musculus
 Cyp1a2ENSMUSG00000032310Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cyp1d1 / cytochrome P450, family 1, subfamily D, polypeptide 1ENSDARG0000003556945
cyp1b1 / cytochrome P450, family 1, subfamily B, polypeptide 1 / Q16678* / Q64429* / Cytochrome P450 1B1 * / cytochrome P450 family 1 subfamily B member 1*ENSDARG0000006893439
cyp1c2 / cytochrome P450, family 1, subfamily C, polypeptide 2ENSDARG0000010178934
cyp17a2 / cytochrome P450, family 17, subfamily A, polypeptide 2ENSDARG0000005396630
cyp17a1 / cytochrome P450, family 17, subfamily A, polypeptide 1 / P05093* / P27786* / Steroid 17-alpha-hydroxylase/17,20 lyase * / cytochrome P450 family 17 subfamily A member 1*ENSDARG0000003356629
cyp2x8 / cytochrome P450, family 2, subfamily X, polypeptide 8 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000004399728
cyp2x6 / cytochrome P450, family 2, subfamily X, polypeptide 6 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000007965328
cyp21a2 / cytochrome P450, family 21, subfamily A, polypeptide 2 / P08686* / Cyp21a1* / cytochrome P450 family 21 subfamily A member 2*ENSDARG0000003755027
cyp2x7 / cytochrome P450, family 2, subfamily X, polypeptide 7 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000004400227
cyp2x10.2 / cytochrome P450, family 2, subfamily X, polypeptide 10.2 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000006828327
cyp2x9 / cytochrome P450, family 2, subfamily X, polypeptide 9ENSDARG0000007077527
cyp2aa4 / cytochrome P450, family 2, subfamily AA, polypeptide 4 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000009880327
cyp2aa11 / cyp2aa12 / cytochrome P450, family 2, subfamily AA, polypeptide 11 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000010280527
cyp2aa11 / cytochrome P450, family 2, subfamily AA, polypeptide 11 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000010345627
cyp2aa2 / y cytochrome P450, family 2, subfamily AA, polypeptide 2 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000010481127
cyp2x10.2 / cytochrome P450, family 2, subfamily X, polypeptide 10.2 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000000650126
cyp2aa1 / cytochrome P450, family 2, subfamily AA, polypeptide 1 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000009900326
cyp2aa3 / cytochrome P450, family 2, subfamily AA, polypeptide 3 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000010334726
cyp2aa8 / cyp2aa9 / cytochrome P450, family 2, subfamily AA, polypeptide 8 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000010454026
cyp2x12 / cytochrome P450, family 2, subfamily X, polypeptide 12 / Cyp2ab1* / cytochrome P450, family 2, subfamily ab, polypeptide 1*ENSDARG0000006829025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008066  Cytochrome P450, E-class, group I, CYP1
 IPR017972  Cytochrome P450, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006725 cellular aromatic compound metabolic process IDA
 biological_processGO:0009410 response to xenobiotic stimulus IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IMP
 biological_processGO:0071466 cellular response to xenobiotic stimulus IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IBA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA


Pathways (from Reactome)
Pathway description
Methylation
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
Xenobiotics
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Aflatoxin activation and detoxification
Biosynthesis of protectins
Biosynthesis of maresin-like SPMs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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