Manteia

ENSMUSG00000033871

Mus musculus

Features

Gene ID:	ENSMUSG00000033871

Biological name :	Ppargc1b

Synonyms :	Peroxisome proliferator-activated receptor gamma coactivator 1-beta / Ppargc1b / Q8VHJ7

Possible biological names infered from orthology :	PPARG coactivator 1 beta / Q86YN6

Species:	Mus musculus

Chr. number:	18
Strand:	-1
Band:	E1
Gene start:	61298136
Gene end:	61400431

Corresponding Affymetrix probe sets:	10459193 (MoGene1.0st) 1449945_at (Mouse Genome 430 2.0 Array) 1457578_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000069431 Ensembl peptide - ENSMUSP00000074771 NCBI entrez gene - 170826 See in Manteia. MGI - MGI:2444934 RefSeq - XM_006525698 RefSeq - NM_133249 RefSeq Peptide - NP_573512 swissprot - Q8VHJ7 Ensembl - ENSMUSG00000033871

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ppargc1b	ENSDARG00000101569	Danio rerio
PPARGC1B	ENSGALG00000043389	Gallus gallus
Q86YN6	ENSG00000155846	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
O70343 / Ppargc1a / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Q9UBK2* / PPARG coactivator 1 alpha*	ENSMUSG00000029167	23
Pprc1 / Q6NZN1 / Mus musculus peroxisome proliferative activated receptor, gamma, coactivator-related 1 (Pprc1), transcript variant 2, mRNA. / Q5VV67* / peroxisome proliferator-activated re...	ENSMUSG00000055491	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR000504	RNA recognition motif domain
IPR034177	PPARGC1B, RNA recognition motif
IPR034605	PGC-1
IPR034621	Peroxisome proliferator-activated receptor gamma coactivator 1-beta
IPR035979	RNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001503	ossification	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	ISO
biological_process	GO:0006390	mitochondrial transcription	IMP
biological_process	GO:0007015	actin filament organization	IMP
biological_process	GO:0010694	positive regulation of alkaline phosphatase activity	IMP
biological_process	GO:0030520	intracellular estrogen receptor signaling pathway	ISO
biological_process	GO:0034614	cellular response to reactive oxygen species	IDA
biological_process	GO:0042327	positive regulation of phosphorylation	IMP
biological_process	GO:0045672	positive regulation of osteoclast differentiation	IMP
biological_process	GO:0045780	positive regulation of bone resorption	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISS
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IBA
biological_process	GO:0051384	response to glucocorticoid	IEA
biological_process	GO:0051591	response to cAMP	IEA
biological_process	GO:0060346	bone trabecula formation	IMP
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0016592	mediator complex	ISO
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003712	transcription coregulator activity	IEA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IBA
molecular_function	GO:0030331	estrogen receptor binding	ISO
molecular_function	GO:0030374	nuclear receptor transcription coactivator activity	ISS
molecular_function	GO:0050682	AF-2 domain binding	ISS

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000005	increased brown fat amount	"increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]	Show Allelic Composition: Tjp1^tm1Sats/Tjp1⁺ Genetic Background: B6.Cg-Tjp1^tm1Sats
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Slc18a2^tm2Kmo/Slc18a2^tm2Kmo Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Ciita^tm1.1Dim/Ciita^tm1.1Dim Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Ciita^tm1.1Dim/Ciita^tm1.1Dim Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001554	increased circulating free fatty acid level	"higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Ciita^tm1.1Dim/Ciita^tm1.1Dim Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001783	decreased white fat amount	"reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc18a2^tm2Kmo/Slc18a2^tm2Kmo Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0002106	abnormal muscle physiology	"anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0002128	abnormal blood circulation	"failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0002188	small heart	"reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ciita^tm1.1Dim/Ciita^tm1.1Dim Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ciita^tm1.1Dim/Ciita^tm1.1Dim Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0002702	decreased circulating free fatty acid level	"lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ciita^tm1.1Dim/Ciita^tm1.1Dim Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0002970	abnormal white fat morphology	"structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0002971	abnormal brown fat morphology	"defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0003393	decreased cardiac output	"reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0003916	decreased left ventricle weight	"less than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0004993	decreased bone resorption	"reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: T^c-2H/T⁺ Genetic Background: involves: 101/H * C3H/HeH
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0005266	abnormal metabolism	"anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0005290	decreased oxygen consumption	"less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0005318	decreased triglyceride level	"lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa13^tm1Ipc/Hoxa13⁺,Hoxd13^spdh/Hoxd13⁺ Genetic Background: involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Atm^tm1Awb/Atm^tm1Awb,Nbn^tm2.1Jpt/Nbn^tm2.1Jpt Genetic Background: involves: 129S6/SvEvTac * 129/Sv
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0006035	abnormal mitochondrial morphology	"anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Ppargc1b^tm1Lowl/Ppargc1b^tm1Lowl Genetic Background: involves: C57BL/6
MP:0006036	abnormal mitochondrial physiology		Show Allelic Composition: Ppargc1b^tm1Lowl/Ppargc1b^tm1Lowl Genetic Background: involves: C57BL/6 Allelic Composition: Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi,Tg(Fabp4-cre)1Rev/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: T^c-2H/T⁺ Genetic Background: involves: 101/H * C3H/HeH
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0009115	abnormal fat cell morphology	"any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0009116	abnormal brown fat cell morphology	"any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]	Show Allelic Composition: Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi,Tg(Fabp4-cre)1Rev/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009118	increased white fat cell size	"increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0009124	increased brown fat cell lipid droplet size	"increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi,Tg(Fabp4-cre)1Rev/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009137	decreased brown fat lipid droplet number	"reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi,Tg(Fabp4-cre)1Rev/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009283	decreased gonadal fat pad weight	"less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppargc1b^tm1Lowl/Ppargc1b^tm1Lowl Genetic Background: involves: C57BL/6
MP:0010955	abnormal respiratory electron transport chain	"anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]	Show Allelic Composition: Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi,Tg(Fabp4-cre)1Rev/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010958	abnormal tricarboxylic acid cycle	"any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]	Show Allelic Composition: Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi,Tg(Fabp4-cre)1Rev/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010959	abnormal oxidative phosphorylation	"any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]	Show Allelic Composition: Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi,Tg(Fabp4-cre)1Rev/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011049	impaired adaptive thermogenesis	"inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]	Show Allelic Composition: Ciita^tm1.1Dim/Ciita^tm1.1Dim Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b⁺ Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ciita^tm1.1Dim/Ciita^tm1.1Dim Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk,Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N
MP:0012106	impaired exercise endurance	"impaired performance during controlled physical activity" [MGI:smb]	Show Allelic Composition: Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk Genetic Background: involves: 129X1/SvJ * FVB/N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000058440	Nrf1 / Q9WU00 / nuclear respiratory factor 1 / Q16656*	/ complex / reaction
ENSMUSG00000024955	Esrra / O08580 / Steroid hormone receptor ERR1 / P11474* / estrogen related receptor alpha*	/ complex

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