ENSMUSG00000034055


Mus musculus

Features
Gene ID: ENSMUSG00000034055
  
Biological name :Phka1
  
Synonyms : P18826 / Phka1 / Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
  
Possible biological names infered from orthology : P46020 / phosphorylase kinase regulatory subunit alpha 1
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 102513975
Gene end: 102644246
  
Corresponding Affymetrix probe sets: 10606102 (MoGene1.0st)   1422743_at (Mouse Genome 430 2.0 Array)   1422744_at (Mouse Genome 430 2.0 Array)   1435567_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061991
Ensembl peptide - ENSMUSP00000114066
Ensembl peptide - ENSMUSP00000113302
Ensembl peptide - ENSMUSP00000112529
Ensembl peptide - ENSMUSP00000109241
Ensembl peptide - ENSMUSP00000042778
NCBI entrez gene - 18679     See in Manteia.
MGI - MGI:97576
RefSeq - XM_017318427
RefSeq - NM_008832
RefSeq - NM_173021
RefSeq - XM_006527894
RefSeq - XM_006527895
RefSeq Peptide - NP_032858
RefSeq Peptide - NP_766609
swissprot - A2AI87
swissprot - A2AI89
swissprot - P18826
swissprot - A2AI88
swissprot - A2AI91
Ensembl - ENSMUSG00000034055
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PHKA1ENSGALG00000004801Gallus gallus
 PHKA1ENSG00000067177Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phka2 / Q8BWJ3 / Phosphorylase b kinase regulatory subunit alpha, liver isoform / P46019* / phosphorylase kinase regulatory subunit alpha 2*ENSMUSG0000003129567
Phkb / Q7TSH2 / Phosphorylase b kinase regulatory subunit beta / Q93100* / phosphorylase kinase regulatory subunit beta*ENSMUSG0000003687930


Protein motifs (from Interpro)
Interpro ID Name
 IPR008734  Phosphorylase kinase alpha/beta subunit
 IPR008928  Six-hairpin glycosidase superfamily
 IPR011613  GH15-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005964 phosphorylase kinase complex IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004689 phosphorylase kinase activity IBA
 molecular_functionGO:0005516 calmodulin binding IEA


Pathways (from Reactome)
Pathway description
Glycogen breakdown (glycogenolysis)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T/twPas2
Genetic Background: involves: M. m. brevirostris

Allelic Composition: Phka1I/FnLn/Phka1+
Genetic Background: (C57BL/FnLn x I/FnLn)F1

Allelic Composition: Phka1I/FnLn/Phka1+
Genetic Background: (I/FnLn x C57BL/FnLn)F1

Allelic Composition: Phka1I/FnLn/Y
Genetic Background: (I/FnLn x C57BL/FnLn)F1

Allelic Composition: Phka1I/FnLn/Y
Genetic Background: I/FnLn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025537 Phkg1 / P07934 / Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform / Q16816* / phosphorylase kinase catalytic subunit gamma 1*  / complex
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex
 ENSMUSG00000032648 Pygm / Q9WUB3 / Glycogen phosphorylase, muscle form / P11217* / glycogen phosphorylase, muscle associated*  / reaction
 ENSMUSG00000034055 Phka1 / P18826 / Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform / P46020* / phosphorylase kinase regulatory subunit alpha 1*  / complex
 ENSMUSG00000036879 Phkb / Q7TSH2 / Phosphorylase b kinase regulatory subunit beta / Q93100* / phosphorylase kinase regulatory subunit beta*  / complex






 

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