ENSMUSG00000035000


Mus musculus

Features
Gene ID: ENSMUSG00000035000
  
Biological name :Dpp4
  
Synonyms : Dipeptidyl peptidase 4 Dipeptidyl peptidase 4 membrane form Dipeptidyl peptidase 4 soluble form / Dpp4 / P28843
  
Possible biological names infered from orthology : dipeptidyl peptidase 4 / P27487
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.3
Gene start: 62330073
Gene end: 62412231
  
Corresponding Affymetrix probe sets: 10483046 (MoGene1.0st)   1416697_at (Mouse Genome 430 2.0 Array)   1438279_at (Mouse Genome 430 2.0 Array)   1441342_at (Mouse Genome 430 2.0 Array)   1459973_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044050
NCBI entrez gene - 13482     See in Manteia.
MGI - MGI:94919
RefSeq - XM_011239274
RefSeq - NM_001159543
RefSeq - NM_010074
RefSeq - XM_006498691
RefSeq - XM_006498692
RefSeq Peptide - NP_001153015
RefSeq Peptide - NP_034204
swissprot - P28843
Ensembl - ENSMUSG00000035000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpp4ENSDARG00000079420Danio rerio
 fapENSDARG00000078468Danio rerio
 DPP4ENSGALG00000042452Gallus gallus
 DPP4ENSG00000197635Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fap / P97321 / Prolyl endopeptidase FAP Antiplasmin-cleaving enzyme FAP, soluble form / Q12884* / fibroblast activation protein alpha*ENSMUSG0000000039252
Dpp10 / dipeptidyl peptidase like 10 / Q8N608*ENSMUSG0000003681534
Dpp6 / Q9Z218 / Dipeptidyl aminopeptidase-like protein 6 / P42658* / dipeptidyl peptidase like 6*ENSMUSG0000006157631
Dpp8 / Q80YA7 / Dipeptidyl peptidase 8 / Q6V1X1*ENSMUSG0000003239324
Dpp9 / Q8BVG4 / Dipeptidyl peptidase 9 / Q86TI2*ENSMUSG0000000122923


Protein motifs (from Interpro)
Interpro ID Name
 IPR001375  Peptidase S9, prolyl oligopeptidase, catalytic domain
 IPR002469  Dipeptidylpeptidase IV, N-terminal domain
 IPR002471  Peptidase S9, serine active site
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010716 negative regulation of extracellular matrix disassembly IEA
 biological_processGO:0031295 T cell costimulation IEA
 biological_processGO:0033632 regulation of cell-cell adhesion mediated by integrin IEA
 biological_processGO:0035641 locomotory exploration behavior IMP
 biological_processGO:0036343 psychomotor behavior IMP
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0046718 viral entry into host cell IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0046581 intercellular canaliculus IDA
 cellular_componentGO:0071438 invadopodium membrane ISO
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity ISO
 molecular_functionGO:0008239 dipeptidyl-peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014351 Gip / P48756 / Gastric inhibitory polypeptide / P09681*  / reaction
 ENSMUSG00000000394 Gcg / P55095 / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like pepti...  / reaction






 

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