ENSMUSG00000035232


Mus musculus

Features
Gene ID: ENSMUSG00000035232
  
Biological name :Pdk3
  
Synonyms : Pdk3 / pyruvate dehydrogenase kinase, isoenzyme 3 / Q922H2
  
Possible biological names infered from orthology : pyruvate dehydrogenase kinase 3 / Q15120
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: C3
Gene start: 93764607
Gene end: 93832201
  
Corresponding Affymetrix probe sets: 10605711 (MoGene1.0st)   1426410_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036604
NCBI entrez gene - 236900     See in Manteia.
MGI - MGI:2384308
RefSeq - NM_145630
RefSeq Peptide - NP_663605
swissprot - Q4FJR4
swissprot - Q922H2
Ensembl - ENSMUSG00000035232
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdk3aENSDARG00000014527Danio rerio
 pdk3bENSDARG00000099791Danio rerio
 PDK3ENSGALG00000016323Gallus gallus
 PDK3ENSG00000067992Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdk1 / Q8BFP9 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial / Q15118* / pyruvate dehydrogenase kinase 1*ENSMUSG0000000649467
Pdk2 / Q9JK42 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial / Q15119* / pyruvate dehydrogenase kinase 2*ENSMUSG0000003896767
Pdk4 / O70571 / pyruvate dehydrogenase kinase, isoenzyme 4 / Q16654* / pyruvate dehydrogenase kinase 4*ENSMUSG0000001957760
Bckdk / O55028 / [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial / O14874* / branched chain ketoacid dehydrogenase kinase*ENSMUSG0000003080226


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR005467  Histidine kinase domain
 IPR018955  Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
 IPR036784  Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate IEA
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0035357 peroxisome proliferator activated receptor signaling pathway IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0097411 hypoxia-inducible factor-1alpha signaling pathway ISS
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity ISO
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010914 Pdhx / Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial / O00330* / pyruvate dehydrogenase complex component X*  / reaction
 ENSMUSG00000021748 Pdhb / Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / pyruvate dehydrogenase E1 beta subunit*  / reaction
 ENSMUSG00000031299 Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*  / reaction
 ENSMUSG00000000168 Dlat / Q8BMF4 / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515* / dihydrolipoamide S-acetyltransferase*  / reaction
 ENSMUSG00000047674 Pdha2 / P35487 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial / P29803* / pyruvate dehydrogenase E1 alpha 2 subunit*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / reaction






 

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