ENSMUSG00000020664


Mus musculus

Features
Gene ID: ENSMUSG00000020664
  
Biological name :Dld
  
Synonyms : Dihydrolipoyl dehydrogenase, mitochondrial / Dld / O08749
  
Possible biological names infered from orthology : dihydrolipoamide dehydrogenase / P09622
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A2
Gene start: 31331277
Gene end: 31351453
  
Corresponding Affymetrix probe sets: 10399825 (MoGene1.0st)   1423159_at (Mouse Genome 430 2.0 Array)   1433263_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106481
NCBI entrez gene - 13382     See in Manteia.
MGI - MGI:107450
RefSeq - NM_007861
RefSeq Peptide - NP_031887
swissprot - O08749
Ensembl - ENSMUSG00000020664
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dldhENSDARG00000008785Danio rerio
 DLDENSGALG00000007931Gallus gallus
 DLDENSG00000091140Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001100  Pyridine nucleotide-disulphide oxidoreductase, class I
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006258  Dihydrolipoamide dehydrogenase
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006086 acetyl-CoA biosynthetic process from pyruvate IEA
 biological_processGO:0006103 2-oxoglutarate metabolic process IEA
 biological_processGO:0006120 mitochondrial electron transport, NADH to ubiquinone IMP
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0009106 lipoate metabolic process IEA
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0048240 sperm capacitation IDA
 biological_processGO:0051068 dihydrolipoamide metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate ISO
 biological_processGO:0106077 histone succinylation IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043159 acrosomal matrix IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045252 oxoglutarate dehydrogenase complex IEA
 cellular_componentGO:0045254 pyruvate dehydrogenase complex IEA
 molecular_functionGO:0004148 dihydrolipoyl dehydrogenase activity IMP
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0034604 pyruvate dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0043544 lipoamide binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Glycine degradation
Pyruvate metabolism
Branched-chain amino acid catabolism
Lysine catabolism
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000340 Dbt / P53395 / Mus musculus dihydrolipoamide branched chain transacylase E2 (Dbt), transcript variant 2, mRNA. / P11182* / dihydrolipoamide branched chain transacylase E2*  / complex
 ENSMUSG00000020456 Ogdh / Q60597 / 2-oxoglutarate dehydrogenase, mitochondrial / Q02218* / oxoglutarate dehydrogenase*  / complex
 ENSMUSG00000006494 Pdk1 / Q8BFP9 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial / Q15118* / pyruvate dehydrogenase kinase 1*  / reaction
 ENSMUSG00000019577 Pdk4 / O70571 / pyruvate dehydrogenase kinase, isoenzyme 4 / Q16654* / pyruvate dehydrogenase kinase 4*  / reaction
 ENSMUSG00000010914 Pdhx / Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial / O00330* / pyruvate dehydrogenase complex component X*  / complex
 ENSMUSG00000021748 Pdhb / Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / pyruvate dehydrogenase E1 beta subunit*  / complex
 ENSMUSG00000031299 Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*  / complex
 ENSMUSG00000037826 Ppm1k / Q8BXN7 / protein phosphatase 1K (PP2C domain containing) / Q8N3J5* / protein phosphatase, Mg2+/Mn2+ dependent 1K*  / reaction
 ENSMUSG00000038967 Pdk2 / Q9JK42 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial / Q15119* / pyruvate dehydrogenase kinase 2*  / reaction
 ENSMUSG00000032263 Bckdhb / Q6P3A8 / 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial / P21953* / branched chain keto acid dehydrogenase E1 subunit beta*  / complex
 ENSMUSG00000000168 Dlat / Q8BMF4 / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515* / dihydrolipoamide S-acetyltransferase*  / complex
 ENSMUSG00000004789 Dlst / Q9D2G2 / Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial / P36957* / dihydrolipoamide S-succinyltransferase*  / complex
 ENSMUSG00000060376 Bckdha / branched chain ketoacid dehydrogenase E1, alpha polypeptide / P12694* / branched chain keto acid dehydrogenase E1, alpha polypeptide*  / complex
 ENSMUSG00000035232 Pdk3 / Q922H2 / pyruvate dehydrogenase kinase, isoenzyme 3 / Q15120* / pyruvate dehydrogenase kinase 3*  / reaction
 ENSMUSG00000030802 Bckdk / O55028 / [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial / O14874* / branched chain ketoacid dehydrogenase kinase*  / reaction
 ENSMUSG00000047674 Pdha2 / P35487 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial / P29803* / pyruvate dehydrogenase E1 alpha 2 subunit*  / complex
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / complex






 

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