ENSDARG00000008785


Danio rerio

Features
Gene ID: ENSDARG00000008785
  
Biological name :dldh
  
Synonyms : dihydrolipoamide dehydrogenase / dldh
  
Possible biological names infered from orthology : Dihydrolipoyl dehydrogenase, mitochondrial / DLD / O08749 / P09622
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 26877705
Gene end: 26893006
  
Corresponding Affymetrix probe sets: Dr.1051.1.S1_at (Zebrafish Array)   NM_201506_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000017217
NCBI entrez gene - 399479     See in Manteia.
RefSeq - NM_201506
RefSeq Peptide - NP_958914
swissprot - Q6TNU6
ZFIN ID - ZDB-GENE-040120-4
Ensembl - ENSDARG00000008785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DLDENSGALG00000007931Gallus gallus
 DLDENSG00000091140Homo sapiens
 DldENSMUSG00000020664Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006258  Dihydrolipoamide dehydrogenase
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060047 heart contraction IMP
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0004148 dihydrolipoyl dehydrogenase activity IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Glycine degradation
Pyruvate metabolism
Branched-chain amino acid catabolism
Lysine catabolism
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000021346 pdhb / pyruvate dehydrogenase E1 beta subunit / P11177* / Q9D051* / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial *  / complex
 ENSDARG00000008785 dldh / dihydrolipoamide dehydrogenase / DLD* / O08749* / P09622* / Dihydrolipoyl dehydrogenase, mitochondrial *  / complex
 ENSDARG00000015918 dlat / dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) / P10515* / Q8BMF4* / dihydrolipoamide S-acetyltransferase* / Dihydrolipoyllysine-residue acetyl...  / complex
 ENSDARG00000040555 bckdha / branched chain keto acid dehydrogenase E1, alpha polypeptide / P12694* / AC011462.1* / branched chain ketoacid dehydrogenase E1, alpha polypeptide*  / complex
 ENSDARG00000105187 gcshb / glycine cleavage system protein H (aminomethyl carrier), b / GCSH* / P23434* / Q91WK5* / AC092718.3* / AC092718.8* / glycine cleavage system protein H* / Glycine cleavage system H p...  / reaction
 ENSDARG00000020876 pdk2a / pyruvate dehydrogenase kinase, isozyme 2a / PDK2* / Q9JK42* / Q15119* / pyruvate dehydrogenase kinase 2* / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial *  / reaction
 ENSDARG00000016904 bckdk / branched chain ketoacid dehydrogenase kinase / O14874* / O55028* / [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial *  / reaction
 ENSDARG00000013128 pdk1 / pyruvate dehydrogenase kinase, isozyme 1 / Q15118* / Q8BFP9* / pyruvate dehydrogenase kinase 1* / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial *  / reaction
 ENSDARG00000054848 pdk4 / pyruvate dehydrogenase kinase, isozyme 4 / O70571* / Q16654* / pyruvate dehydrogenase kinase 4* / pyruvate dehydrogenase kinase, isoenzyme 4*  / reaction
 ENSDARG00000051756 pdhx / pyruvate dehydrogenase complex, component X / O00330* / Q8BKZ9* / Pyruvate dehydrogenase protein X component, mitochondrial *  / complex
 ENSDARG00000099791 pdk3b / pyruvate dehydrogenase kinase, isozyme 3b / PDK3* / Q922H2* / Q15120* / pyruvate dehydrogenase kinase 3* / pyruvate dehydrogenase kinase, isoenzyme 3*  / reaction






 

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