ENSMUSG00000000168


Mus musculus

Features
Gene ID: ENSMUSG00000000168
  
Biological name :Dlat
  
Synonyms : Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / Dlat / Q8BMF4
  
Possible biological names infered from orthology : dihydrolipoamide S-acetyltransferase / P10515
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 50634633
Gene end: 50659780
  
Corresponding Affymetrix probe sets: 10593367 (MoGene1.0st)   1420155_at (Mouse Genome 430 2.0 Array)   1426264_at (Mouse Genome 430 2.0 Array)   1426265_x_at (Mouse Genome 430 2.0 Array)   1452005_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034567
NCBI entrez gene - 235339     See in Manteia.
MGI - MGI:2385311
RefSeq - NM_145614
RefSeq Peptide - NP_663589
swissprot - Q8BMF4
Ensembl - ENSMUSG00000000168
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlatENSDARG00000015918Danio rerio
 DLATENSGALG00000007904Gallus gallus
 DLATENSG00000150768Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdhx / Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial / O00330* / pyruvate dehydrogenase complex component X*ENSMUSG0000001091427


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001078  2-oxoacid dehydrogenase acyltransferase, catalytic domain
 IPR003016  2-oxo acid dehydrogenase, lipoyl-binding site
 IPR004167  Peripheral subunit-binding domain
 IPR006257  Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
 IPR011053  Single hybrid motif
 IPR036625  E3-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006086 acetyl-CoA biosynthetic process from pyruvate IEA
 biological_processGO:0006090 pyruvate metabolic process IEA
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030431 sleep IEA
 biological_processGO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005967 mitochondrial pyruvate dehydrogenase complex TAS
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045254 pyruvate dehydrogenase complex TAS
 molecular_functionGO:0004742 dihydrolipoyllysine-residue acetyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0034604 pyruvate dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006494 Pdk1 / Q8BFP9 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial / Q15118* / pyruvate dehydrogenase kinase 1*  / reaction
 ENSMUSG00000019577 Pdk4 / O70571 / pyruvate dehydrogenase kinase, isoenzyme 4 / Q16654* / pyruvate dehydrogenase kinase 4*  / reaction
 ENSMUSG00000010914 Pdhx / Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial / O00330* / pyruvate dehydrogenase complex component X*  / complex
 ENSMUSG00000021748 Pdhb / Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / pyruvate dehydrogenase E1 beta subunit*  / complex
 ENSMUSG00000031299 Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*  / complex
 ENSMUSG00000038967 Pdk2 / Q9JK42 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial / Q15119* / pyruvate dehydrogenase kinase 2*  / reaction
 ENSMUSG00000000168 Dlat / Q8BMF4 / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515* / dihydrolipoamide S-acetyltransferase*  / complex
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / complex
 ENSMUSG00000035232 Pdk3 / Q922H2 / pyruvate dehydrogenase kinase, isoenzyme 3 / Q15120* / pyruvate dehydrogenase kinase 3*  / reaction
 ENSMUSG00000047674 Pdha2 / P35487 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial / P29803* / pyruvate dehydrogenase E1 alpha 2 subunit*  / complex






 

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