ENSMUSG00000035437


Mus musculus
gtpaseRabgap1domainactivityproteinregulationrab-gtpase-tbcsuperfamilyrabintracellularbindingptbpiph-likekinesin-likegtpase-activatingtransportcellcyclevesiclefusionactivationcytoplasmmicrotubuleorganizingcentercytosolcytoskeletonendomembraneactivatortbc

Features
Gene ID: ENSMUSG00000035437
  
Biological name :Rabgap1
  
Synonyms : A2AWA9 / Rabgap1 / RAB GTPase activating protein 1
  
Possible biological names infered from orthology : Q9Y3P9
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 37443279
Gene end: 37566454
  
Corresponding Affymetrix probe sets: 10471784 (MoGene1.0st)   1424188_at (Mouse Genome 430 2.0 Array)   1441555_at (Mouse Genome 430 2.0 Array)   1441800_at (Mouse Genome 430 2.0 Array)   1443535_at (Mouse Genome 430 2.0 Array)   1460486_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061624
Ensembl peptide - ENSMUSP00000121963
Ensembl peptide - ENSMUSP00000119831
Ensembl peptide - ENSMUSP00000108542
Ensembl peptide - ENSMUSP00000068835
NCBI entrez gene - 227800     See in Manteia.
MGI - MGI:2385139
RefSeq - XM_006497997
RefSeq - NM_001033960
RefSeq - NM_146121
RefSeq - XM_006497994
RefSeq - XM_006497995
RefSeq - XM_006497996
RefSeq Peptide - NP_001029132
RefSeq Peptide - NP_666233
swissprot - A2AWA9
swissprot - A2AWA7
swissprot - A2AWB0
swissprot - B2RRC5
Ensembl - ENSMUSG00000035437
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rabgap1ENSDARG00000098967Danio rerio
 RABGAP1ENSGALG00000001225Gallus gallus
 Q9Y3P9ENSG00000011454Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A6H6A9 / Rabgap1l / Rab GTPase-activating protein 1-like / B7ZAP0* / Q5R372*ENSMUSG0000002672150
Q60949 / Tbc1d1 / TBC1 domain family, member 1 / Q86TI0*ENSMUSG0000002917420
Tbc1d4 / TBC1 domain family member 4 / O60343*ENSMUSG0000003308320
Evi5 / ecotropic viral integration site 5 / O60447*ENSMUSG0000001183119
Evi5l / Mus musculus ecotropic viral integration site 5 like (Evi5l), transcript variant 2, mRNA. / Q96CN4* / ecotropic viral integration site 5 like*ENSMUSG0000001183217
Tbc1d14 / TBC1 domain family, member 14 / Q9P2M4*ENSMUSG0000002919212
Tbc1d12 / TBC1 domain family member 12 / O60347*ENSMUSG0000004872010


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR022164  Kinesin-like
 IPR033185  Rab GTPase-activating protein 1
 IPR035969  Rab-GTPase-TBC domain superfamily


Gene Ontology (GO)
macromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell cyclecellular component organizationregulation of molecular functionmacromolecule localizatmacromolecule localizationestablishment of localiestablishment of localizationcellular localizationcellular localizationcell cyclecell cyclecellular component orgacellular component organizationregulation of molecularregulation of molecular function
enzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityenzyme regulator activityprotein bindingprotein binding
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0031338 regulation of vesicle fusion IBA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0090630 activation of GTPase activity IBA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0012505 endomembrane system IBA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / complex / reaction






 

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