ENSMUSG00000035847


Mus musculus

Features
Gene ID: ENSMUSG00000035847
  
Biological name :Ids
  
Synonyms : Ids / Iduronate 2-sulfatase / Q08890
  
Possible biological names infered from orthology : AC244197.3 / P22304
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.2
Gene start: 70343069
Gene end: 70365084
  
Corresponding Affymetrix probe sets: 10604906 (MoGene1.0st)   1421216_a_at (Mouse Genome 430 2.0 Array)   1427812_at (Mouse Genome 430 2.0 Array)   1434751_at (Mouse Genome 430 2.0 Array)   1450166_at (Mouse Genome 430 2.0 Array)   1455481_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099046
Ensembl peptide - ENSMUSP00000118732
NCBI entrez gene - 15931     See in Manteia.
MGI - MGI:96417
RefSeq - XM_017318394
RefSeq - NM_010498
RefSeq - XM_006527845
RefSeq - XM_006527846
RefSeq - XM_017318393
RefSeq Peptide - NP_034628
swissprot - Q08890
swissprot - F6X9C5
Ensembl - ENSMUSG00000035847
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 idsENSDARG00000071699Danio rerio
 IDSENSGALG00000009154Gallus gallus
 AC244197.3ENSG00000241489Homo sapiens
 IDSENSG00000010404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arsk / arylsulfatase family member K / Q6UWY0*ENSMUSG0000002159222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000917  Sulfatase, N-terminal
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR024607  Sulfatase, conserved site
 IPR035874  Iduronate-2-sulfatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005764 lysosome IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004423 iduronate-2-sulfatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008484 sulfuric ester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HS-GAG degradation
CS/DS degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt5atm1.1Tpy/Wnt5atm1.1Tpy,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001296 macrophthalmia "increased average size of the eyes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Idstm1Eto/Idstm1Eto
Genetic Background: involves: C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Idstm1Eto/Idstm1Eto
Genetic Background: involves: C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Idstm1Eto/Idstm1Eto
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0003795 abnormal bone structure 
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Allelic Composition: Idstm1Eto/Idstm1Eto
Genetic Background: involves: C57BL/6

 MP:0005059 lysosomal protein accumulation "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Idstm1Eto/Idstm1Eto
Genetic Background: involves: C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Idstm1Eto/Idstm1Eto
Genetic Background: involves: C57BL/6

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0009877 exostosis "a projection of bone, sometimes a benign tumor, that is capped by cartilage and arises from a bone that develops from cartilage" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Idstm1Eto/Idstm1Eto
Genetic Background: involves: C57BL/6

 MP:0030074 coarse facial features "absence of fine and sharp appearance of facial features, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues" [HP:0000280]
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Allelic Composition: Idstm1Eto/Idstm1Eto
Genetic Background: involves: C57BL/6

 MP:0030188 round snout "appearance of the anterior facial part of the face or muzzle containing the oral and nasal regions is more circular than usual" [MGI:anna]
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Allelic Composition: Idstm1Eto/Idstm1Eto
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035847 Ids / Q08890 / Iduronate 2-sulfatase / P22304* / AC244197.3*  / complex






 

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