ENSMUSG00000036251


Mus musculus

Features
Gene ID: ENSMUSG00000036251
  
Biological name :Trpm8
  
Synonyms : Q8R4D5 / Transient receptor potential cation channel subfamily M member 8 / Trpm8
  
Possible biological names infered from orthology : Q7Z2W7
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 88277661
Gene end: 88389293
  
Corresponding Affymetrix probe sets: 10348378 (MoGene1.0st)   1421617_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036991
Ensembl peptide - ENSMUSP00000108739
Ensembl peptide - ENSMUSP00000131209
NCBI entrez gene - 171382     See in Manteia.
MGI - MGI:2181435
RefSeq - XM_017319118
RefSeq - NM_134252
RefSeq - XM_006529225
RefSeq - XM_006529226
RefSeq Peptide - NP_599013
swissprot - Q8R4D5
Ensembl - ENSMUSG00000036251
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRPM8ENSGALG00000004116Gallus gallus
 TRPM8ENSG00000144481Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpm2 / Q91YD4 / Transient receptor potential cation channel subfamily M member 2 / O94759*ENSMUSG0000000929242
Trpm4 / Q7TN37 / Transient receptor potential cation channel subfamily M member 4 / Q8TD43*ENSMUSG0000003826032
Trpm5 / Q9JJH7 / Transient receptor potential cation channel subfamily M member 5 / Q9NZQ8*ENSMUSG0000000924631
Trpm1 / Q2TV84 / Transient receptor potential cation channel subfamily M member 1 / Q7Z4N2*ENSMUSG0000003052329
Trpm3 / transient receptor potential cation channel, subfamily M, member 3 / Q9HCF6*ENSMUSG0000005238729
Trpm7 / Q923J1 / Transient receptor potential cation channel subfamily M member 7 / Q96QT4*ENSMUSG0000002736527
Trpm6 / Q8CIR4 / Transient receptor potential cation channel subfamily M member 6 / Q9BX84*ENSMUSG0000002472726


Protein motifs (from Interpro)
Interpro ID Name
 IPR029603  Transient receptor potential cation channel subfamily M member 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0009266 response to temperature stimulus IDA
 biological_processGO:0009409 response to cold IMP
 biological_processGO:0016048 detection of temperature stimulus IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050951 sensory perception of temperature stimulus IEA
 biological_processGO:0050955 thermoception IMP
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0070207 protein homotrimerization IDA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005216 ion channel activity IDA
 molecular_functionGO:0005262 calcium channel activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Jag1Mhdahtu/Jag1Slalom
Genetic Background: involves: BALB/c * C3H * C3HeB/FeJ

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Jag1Mhdahtu/Jag1Slalom
Genetic Background: involves: BALB/c * C3H * C3HeB/FeJ

Allelic Composition: Trpm8tm1Lex/Trpm8tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Trpm8tm1Apat/Trpm8tm1Apat
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpm8tm1Lex/Trpm8tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Trpm8tm1Apat/Trpm8tm1Apat
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003663 abnormal thermosensation "defect in the ability to sense or display a preference for a given temperature" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96549]
Show

Allelic Composition: Jag1Mhdahtu/Jag1Slalom
Genetic Background: involves: BALB/c * C3H * C3HeB/FeJ

Allelic Composition: Trpm8tm1Lex/Trpm8tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Trpm8tm1Apat/Trpm8tm1Apat
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Trpm8tm1Lex/Trpm8tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Trpm8tm1Apat/Trpm8tm1Apat
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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