ENSMUSG00000038260


Mus musculus

Features
Gene ID: ENSMUSG00000038260
  
Biological name :Trpm4
  
Synonyms : Q7TN37 / Transient receptor potential cation channel subfamily M member 4 / Trpm4
  
Possible biological names infered from orthology : Q8TD43
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45302632
Gene end: 45333780
  
Corresponding Affymetrix probe sets: 10563191 (MoGene1.0st)   1435549_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040367
Ensembl peptide - ENSMUSP00000148245
Ensembl peptide - ENSMUSP00000147999
Ensembl peptide - ENSMUSP00000147793
Ensembl peptide - ENSMUSP00000147635
Ensembl peptide - ENSMUSP00000147620
NCBI entrez gene - 68667     See in Manteia.
MGI - MGI:1915917
RefSeq - XM_006541148
RefSeq - NM_175130
RefSeq - XM_006541146
RefSeq Peptide - NP_780339
swissprot - A0A1B0GSM7
swissprot - A0A1B0GT86
swissprot - A0A1B0GRQ4
swissprot - Q7TN37
swissprot - A0A1B0GS49
swissprot - A0A1B0GRR7
Ensembl - ENSMUSG00000038260
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-173d10.1ENSDARG00000063347Danio rerio
 si:ch211-173d10.1ENSDARG00000109442Danio rerio
 trpm4aENSDARG00000059993Danio rerio
 trpm4b.2ENSDARG00000063435Danio rerio
 TRPM4ENSG00000130529Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpm5 / Q9JJH7 / Transient receptor potential cation channel subfamily M member 5 / Q9NZQ8*ENSMUSG0000000924641
Trpm2 / Q91YD4 / Transient receptor potential cation channel subfamily M member 2 / O94759*ENSMUSG0000000929236
Trpm1 / Q2TV84 / Transient receptor potential cation channel subfamily M member 1 / Q7Z4N2*ENSMUSG0000003052329
Trpm8 / Q8R4D5 / Transient receptor potential cation channel subfamily M member 8 / Q7Z2W7*ENSMUSG0000003625129
Trpm7 / Q923J1 / Transient receptor potential cation channel subfamily M member 7 / Q96QT4*ENSMUSG0000002736528
Trpm3 / transient receptor potential cation channel, subfamily M, member 3 / Q9HCF6*ENSMUSG0000005238728
Trpm6 / Q8CIR4 / Transient receptor potential cation channel subfamily M member 6 / Q9BX84*ENSMUSG0000002472726


Protein motifs (from Interpro)
Interpro ID Name
 IPR005821  Ion transport domain
 IPR029581  Transient receptor potential cation channel subfamily M member 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002407 dendritic cell chemotaxis IMP
 biological_processGO:0002724 regulation of T cell cytokine production IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010460 positive regulation of heart rate ISS
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030502 negative regulation of bone mineralization ISS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation ISS
 biological_processGO:0045668 negative regulation of osteoblast differentiation ISS
 biological_processGO:0045907 positive regulation of vasoconstriction ISS
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0061337 cardiac conduction IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071318 cellular response to ATP IDA
 biological_processGO:0086045 membrane depolarization during AV node cell action potential IEA
 biological_processGO:0086047 membrane depolarization during Purkinje myocyte cell action potential IEA
 biological_processGO:0086048 membrane depolarization during bundle of His cell action potential IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0098662 inorganic cation transmembrane transport IDA
 biological_processGO:0098719 sodium ion import across plasma membrane IEA
 biological_processGO:0098911 regulation of ventricular cardiac muscle cell action potential IEA
 biological_processGO:1903949 positive regulation of atrial cardiac muscle cell action potential ISS
 biological_processGO:1904179 positive regulation of adipose tissue development ISS
 biological_processGO:1904199 positive regulation of regulation of vascular smooth muscle cell membrane depolarization ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034706 sodium channel complex IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0044214 spanning component of plasma membrane IEA
 cellular_componentGO:0089717 spanning component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005227 calcium activated cation channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity ISO
 molecular_functionGO:0005262 calcium channel activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

Allelic Composition: Trpm4tm1.1Knt/Trpm4tm1.1Knt,Trpm5tm1Csz/Trpm5tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

Allelic Composition: Trpm4tm1.1Knt/Trpm4tm1.1Knt,Trpm5tm1Csz/Trpm5tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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