ENSMUSG00000036545


Mus musculus
peptidasecollagenactivityAdamts2mbthrombospondintype-tsprepeatadam-tsmetallopeptidasesuperfamilyspermatogenesisfibrildevelopmentprocessskinextracellularionbindingadamreprolysinpropeptidespacerplaccatalyticdomainproteolysisproteinprocessing

Features
Gene ID: ENSMUSG00000036545
  
Biological name :Adamts2
  
Synonyms : Adamts2 / A disintegrin and metalloproteinase with thrombospondin motifs 2 / Q8C9W3
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 2 / O95450
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 50602084
Gene end: 50807573
  
Corresponding Affymetrix probe sets: 10375751 (MoGene1.0st)   1435990_at (Mouse Genome 430 2.0 Array)   1455720_at (Mouse Genome 430 2.0 Array)   1457058_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040171
NCBI entrez gene - 216725     See in Manteia.
MGI - MGI:1347356
RefSeq - NM_175643
RefSeq - XM_011248901
RefSeq Peptide - NP_783574
swissprot - Q8C9W3
Ensembl - ENSMUSG00000036545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts2ENSDARG00000075930Danio rerio
 CABZ01080056.1ENSDARG00000115504Danio rerio
 ADAMTS2ENSGALG00000032974Gallus gallus
 O95450ENSG00000087116Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adamts3 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 / O15072* / ADAM metallopeptidase with thrombospondin type 1 motif 3*ENSMUSG0000004363555
Adamts14 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 / Q8WXS8* / ADAM metallopeptidase with thrombospondin type 1 motif 14*ENSMUSG0000005990149
Q68SA9 / Adamts7 / A disintegrin and metalloproteinase with thrombospondin motifs 7 / Q9UKP4* / ADAM metallopeptidase with thrombospondin type 1 motif 7*ENSMUSG0000003236328
Q69Z28 / Adamts16 / A disintegrin and metalloproteinase with thrombospondin motifs 16 / Q8TE57* / ADAM metallopeptidase with thrombospondin type 1 motif 16*ENSMUSG0000004953828
Q4VC17 / Adamts18 / A disintegrin and metalloproteinase with thrombospondin motifs 18 / Q8TE60* / ADAM metallopeptidase with thrombospondin type 1 motif 18*ENSMUSG0000005339928
Adamts6 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 / Q9UKP5* / ADAM metallopeptidase with thrombospondin type 1 motif 6*ENSMUSG0000004616927
Adamts17 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17 / Q8TE56* / ADAM metallopeptidase with thrombospondin type 1 motif 17*ENSMUSG0000005814527
P58459 / Adamts10 / Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10 (Adamts10), transcript variant 4, mRNA. / Q9H324* / ADAM meta...ENSMUSG0000002429926
Q811B3 / Adamts12 / A disintegrin and metalloproteinase with thrombospondin motifs 12 / P58397* / ADAM metallopeptidase with thrombospondin type 1 motif 12*ENSMUSG0000004749726
P59509 / Adamts19 / A disintegrin and metalloproteinase with thrombospondin motifs 19 / Q8TE59* / ADAM metallopeptidase with thrombospondin type 1 motif 19*ENSMUSG0000005344125


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR013275  Peptidase M12B, ADAM-TS2
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
nitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulticellular organism reproductioncellular component organizationanatomical structure developmentcatabolic processcollagen metabolic processnitrogen compoundnitrogen compound metabolic processprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processmulticellular orgmulticellular organism reproductioncellular componencellular component organizationanatomical structanatomical structure developmentcatabolic processcatabolic processcollagen metabolicollagen metabolic process
catalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteincatalytic activity, acting on a proteinhydrolase activityhydrolase activityion bindingion binding
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0016485 protein processing IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0043588 skin development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
skeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeintegument phenotypecraniofacial phenotypegrowth/size phenotypereproductive system phenotyperespiratory system phenotypecellular phenotypeskeleton phenotypeskeleton phenotypeintegument phenotypeintegument phenotypecraniofacial phenotycraniofacial phenotypegrowth/size phenotypgrowth/size phenotypereproductive system reproductive system phenotyperespiratory system prespiratory system phenotypecellular phenotypecellular phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0012546 triangular face "a face whose lower half becomes relatively thin, approaching an appearance of a triangle with a tip facing downwards; usually associated with a prominent forehead and micrognathia" [MGI:anna]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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