Manteia

ID

Phenotype

Definition

Genetic BG

cleft palate

"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0000284

double outlet right ventricle

"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0000783

abnormal forebrain morphology

"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0000823

abnormal lateral ventricle morphology

"malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0000826

abnormal third ventricle morphology

"malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0000828

abnormal fourth ventricle morphology

"malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0000841

abnormal hindbrain morphology

"malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0003387

coarctation of aorta

"narrowing of the aorta" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0003584

bifid ureter

"cleft of the ureter into two parts or branches" [ncbi:Matthew Mailman, NCBI request]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0003586

ureter dilation

"abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0003826

abnormal Mullerian duct morphology

"malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0003827

abnormal Wolffian duct morphology

"malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0004163

abnormal adenophysis morphology

"any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0004463

basisphenoid bone foramen

"the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0004613

fusion of vertebral arches

"improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0004666

absent stapedial artery

"absence of the small artery that passes through the ring of the stapes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0005244

hemopericardium

"bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0008922

abnormal cervical rib

"alternate location or appearance of a rare supernumerary rib commonly articulating with the seventh cervical vertebrae (above the normal first rib) but not reaching the sternum anteriorly" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0008923

thoracoschisis

"congenital fissure of the chest wall" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0008986

abnormal liver parenchyma morphology

"any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0009770

abnormal optic chiasm morphology

"an anomaly in the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0010418

perimembraneous ventricular septal defect

"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0011100

complete preweaning lethality

"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0011513

abnormal vertebral artery morphology

"any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [ISBN:0-683-40008-8]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0011683

dual inferior vena cava

"presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013186

abnormal basilar artery morphology

"any structural anomaly of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear" [MGI:anna]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013648

increased CD11b-high dendritic cell number

"increase in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [MGI:Saran, PMID:23516985]

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Allelic Composition: A830005F24Rik^{tm1.1(KOMP)Mbp}/A830005F24Rik⁺
Genetic Background: C57BL/6N-A830005F24Rik^{tm1.1(KOMP)Mbp}/Ucd

MP:0013652

decreased CD11b-low dendritic cell number

"reduction in the number of dendritic cells expressing low levels of CD11b which usually express CD8, depend on Irf8 and Batf3 for their development and are responsible for cross-presentation" [MGI:Saran, PMID:23516985]

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Allelic Composition: A830005F24Rik^{tm1.1(KOMP)Mbp}/A830005F24Rik⁺
Genetic Background: C57BL/6N-A830005F24Rik^{tm1.1(KOMP)Mbp}/Ucd

MP:0013823

absent segment of anterior cerebral artery

"absence of a portion of a pair of arteries on the brain that supply oxygen to most medial portions of frontal lobes and superior medial parietal lobes" [MGI:csmith, UBERON:0001624]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013847

retropleural edema

"accumulation of watery or serous fluid in the retropleural space" [MGI:csmith]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013848

subcutaneous edema

"accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013852

abnormal Mullerian duct topology

"aberrant position of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [ISBN:0-683-40008-8]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013859

abnormal vitelline vein connection

"aberrant or missing attachment of the paired veins that carry blood from the yolk sac back to the embryo" [ISBN:0-683-40008-8, MGI:csmith]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013875

trigeminal neuroma

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013876

absent ductus venosus valve

"absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013877

abnormal ductus venosus valve morphology

"any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013878

abnormal ductus venosus valve topology

"abnormal position of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013968

multiple persisting craniopharyngeal ducts

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013986

abnormal vitelline vein topology

"abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith]

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0013992

persistent dorsal ophthalmic artery

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0014019

embryo cyst

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

MP:0014021

heterochrony

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Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu}
Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr

ENSMUSG00000043635