ENSMUSG00000053399


Mus musculus

Features
Gene ID: ENSMUSG00000053399
  
Biological name :Adamts18
  
Synonyms : Adamts18 / A disintegrin and metalloproteinase with thrombospondin motifs 18 / Q4VC17
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 18 / Q8TE60
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 113697126
Gene end: 113848738
  
Corresponding Affymetrix probe sets: 10581961 (MoGene1.0st)   1437574_at (Mouse Genome 430 2.0 Array)   1444253_at (Mouse Genome 430 2.0 Array)   1446247_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148330
Ensembl peptide - ENSMUSP00000090801
Ensembl peptide - ENSMUSP00000148288
NCBI entrez gene - 208936     See in Manteia.
MGI - MGI:2442600
RefSeq - XM_017312630
RefSeq - XM_006530797
RefSeq - XM_006530800
RefSeq - XM_006530801
RefSeq - XM_017312629
RefSeq - NM_172466
RefSeq - XM_006530795
RefSeq Peptide - NP_766054
swissprot - A0A1D5RLE1
swissprot - A0A1D5RLA5
swissprot - Q4VC17
Ensembl - ENSMUSG00000053399
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts18ENSDARG00000001999Danio rerio
 ADAMTS18ENSGALG00000005347Gallus gallus
 Q8TE60ENSG00000140873Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q69Z28 / Adamts16 / A disintegrin and metalloproteinase with thrombospondin motifs 16 / Q8TE57* / ADAM metallopeptidase with thrombospondin type 1 motif 16*ENSMUSG0000004953854
Adamts6 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 / Q9UKP5* / ADAM metallopeptidase with thrombospondin type 1 motif 6*ENSMUSG0000004616935
Q811B3 / Adamts12 / A disintegrin and metalloproteinase with thrombospondin motifs 12 / P58397* / ADAM metallopeptidase with thrombospondin type 1 motif 12*ENSMUSG0000004749735
Q68SA9 / Adamts7 / A disintegrin and metalloproteinase with thrombospondin motifs 7 / Q9UKP4* / ADAM metallopeptidase with thrombospondin type 1 motif 7*ENSMUSG0000003236334
P58459 / Adamts10 / Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10 (Adamts10), transcript variant 4, mRNA. / Q9H324* / ADAM meta...ENSMUSG0000002429933
Adamts17 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17 / Q8TE56* / ADAM metallopeptidase with thrombospondin type 1 motif 17*ENSMUSG0000005814531
P59509 / Adamts19 / A disintegrin and metalloproteinase with thrombospondin motifs 19 / Q8TE59* / ADAM metallopeptidase with thrombospondin type 1 motif 19*ENSMUSG0000005344129
Q8C9W3 / Adamts2 / A disintegrin and metalloproteinase with thrombospondin motifs 2 / O95450* / ADAM metallopeptidase with thrombospondin type 1 motif 2*ENSMUSG0000003654528
Adamts3 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 / O15072* / ADAM metallopeptidase with thrombospondin type 1 motif 3*ENSMUSG0000004363527
Adamts14 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 / Q8WXS8* / ADAM metallopeptidase with thrombospondin type 1 motif 14*ENSMUSG0000005990126


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0090331 negative regulation of platelet aggregation IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0014222 decreased colon goblet cell number 
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr