ENSMUSG00000036676


Mus musculus

Features
Gene ID: ENSMUSG00000036676
  
Biological name :Tmtc3
  
Synonyms : Tmtc3 / transmembrane and tetratricopeptide repeat containing 3
  
Possible biological names infered from orthology : Q6ZXV5
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D1
Gene start: 100443902
Gene end: 100487350
  
Corresponding Affymetrix probe sets: 10372121 (MoGene1.0st)   1436826_at (Mouse Genome 430 2.0 Array)   1440894_at (Mouse Genome 430 2.0 Array)   1457294_at (Mouse Genome 430 2.0 Array)   1458305_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096921
Ensembl peptide - ENSMUSP00000121473
Ensembl peptide - ENSMUSP00000120025
Ensembl peptide - ENSMUSP00000061470
NCBI entrez gene - 237500     See in Manteia.
MGI - MGI:3036255
RefSeq - XM_006513630
RefSeq - XM_011243451
RefSeq - XM_011243450
RefSeq - XM_011243449
RefSeq - NM_001033332
RefSeq - NM_001110013
RefSeq Peptide - NP_001028504
RefSeq Peptide - NP_001103483
swissprot - D3Z2Z3
swissprot - A0A0R4J173
swissprot - G5E8C4
swissprot - D3YWM5
Ensembl - ENSMUSG00000036676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmtc3ENSDARG00000062846Danio rerio
 ENSGALG00000011198Gallus gallus
 ENSGALG00000033106Gallus gallus
 TMTC3ENSG00000139324Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tmtc4 / Q8BG19 / Transmembrane and TPR repeat-containing protein 4 / Q5T4D3* / transmembrane and tetratricopeptide repeat containing 4*ENSMUSG0000004159428
Tmtc1 / Q3UV71 / Mus musculus transmembrane and tetratricopeptide repeat containing 1 (Tmtc1), transcript variant 2, mRNA. / Q8IUR5* / transmembrane and tetratricopeptide repeat containing 1*ENSMUSG0000003030627
Tmtc2 / Q56A06 / transmembrane and tetratricopeptide repeat containing 2 / Q8N394*ENSMUSG0000003601927
Ogt / Q8CGY8 / UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit / O15294* / O-linked N-acetylglucosamine (GlcNAc) transferase*ENSMUSG0000003416014


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013105  Tetratricopeptide repeat 2
 IPR013618  Domain of unknown function DUF1736
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0010906 abnormal lung bud morphology "any structural anomaly of the primary outgrowth of the embryonic trachea i.e. blunt end of the respiratory diverticulum which grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the anlage of a primary bronchus and all its branches" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6

Allelic Composition: Tmtc3Gt(JST185)Byg/Tmtc3Gt(JST185)Byg
Genetic Background: involves: 129P2/OlaHsd * A/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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