ENSMUSG00000038567


Mus musculus

Features
Gene ID: ENSMUSG00000038567
  
Biological name :Cyp24a1
  
Synonyms : 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / Cyp24a1 / Q64441
  
Possible biological names infered from orthology : cytochrome P450 family 24 subfamily A member 1 / Q07973
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 170482708
Gene end: 170497145
  
Corresponding Affymetrix probe sets: 10490080 (MoGene1.0st)   1418866_at (Mouse Genome 430 2.0 Array)   1418867_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047954
NCBI entrez gene - 13081     See in Manteia.
MGI - MGI:88593
RefSeq - NM_009996
RefSeq Peptide - NP_034126
swissprot - Q3TWW0
swissprot - Q64441
Ensembl - ENSMUSG00000038567
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp24a1ENSDARG00000103277Danio rerio
 CYP24A1ENSGALG00000042279Gallus gallus
 Q07973ENSG00000019186Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DBG1 / Cyp27a1 / Sterol 26-hydroxylase, mitochondrial / Q02318* / cytochrome P450 family 27 subfamily A member 1*ENSMUSG0000002617030
O35084 / Cyp27b1 / 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial / O15528* / cytochrome P450 family 27 subfamily B member 1*ENSMUSG0000000672429
Cyp11b2 / cytochrome P450, family 11, subfamily b, polypeptide 2 / P19099* / P15538* / CYP11B1* / cytochrome P450 family 11 subfamily B member 1* / cytochrome P450 family 11 subfamily B member 2*ENSMUSG0000002258924
Cyp11b1 / cytochrome P450, family 11, subfamily b, polypeptide 1 / P15538* / P19099* / CYP11B2* / cytochrome P450 family 11 subfamily B member 2* / cytochrome P450 family 11 subfamily B member 1*ENSMUSG0000007560424
Q9QZ82 / Cyp11a1 / Cholesterol side-chain cleavage enzyme, mitochondrial / P05108* / cytochrome P450 family 11 subfamily A member 1*ENSMUSG0000003232323
Q64464 / Cyp3a13 / Cytochrome P450 3A13 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000002972721
Cyp3a44 / cytochrome P450, family 3, subfamily a, polypeptide 44 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000005441720
Q64459 / Cyp3a11 / Cytochrome P450 3A11 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000005603520
Q9JMA7 / Cyp3a41a / Cytochrome P450 3A41 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P45...ENSMUSG0000007555120
Q9JMA7 / Cyp3a41b / Cytochrome P450 3A41 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P45...ENSMUSG0000007555220
Q9WVK8 / Cyp46a1 / Cholesterol 24-hydroxylase / Q9Y6A2* / cytochrome P450 family 46 subfamily A member 1*ENSMUSG0000002125919
O09158 / Cyp3a25 / Cytochrome P450 3A25 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000002963019
Q64481 / Cyp3a16 / Cytochrome P450 3A16 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000003865619
Cyp3a57 / cytochrome P450, family 3, subfamily a, polypeptide 57 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000007041919
Cyp3a59 / cytochrome P450, family 3, subfamily a, polypeptide 59 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000006129218
P36423 / Tbxas1 / thromboxane A synthase 1, platelet / P24557* / thromboxane A synthase 1*ENSMUSG0000002992517


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0042359 vitamin D metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008403 25-hydroxycholecalciferol-24-hydroxylase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
Vitamins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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