ENSMUSG00000075604


Mus musculus

Features
Gene ID: ENSMUSG00000075604
  
Biological name :Cyp11b1
  
Synonyms : Cyp11b1 / cytochrome P450, family 11, subfamily b, polypeptide 1
  
Possible biological names infered from orthology : CYP11B2 / cytochrome P450 family 11 subfamily B member 1 / cytochrome P450 family 11 subfamily B member 2 / P15538 / P19099
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 74834125
Gene end: 74841643
  
Corresponding Affymetrix probe sets: 10429538 (MoGene1.0st)   1456362_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127888
NCBI entrez gene - 110115     See in Manteia.
MGI - MGI:88583
RefSeq - NM_001033229
RefSeq Peptide - NP_001028401
swissprot - Q3TG86
Ensembl - ENSMUSG00000075604
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp11c1ENSDARG00000042014Danio rerio
 P15538ENSG00000160882Homo sapiens
 P19099ENSG00000179142Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp11b2 / cytochrome P450, family 11, subfamily b, polypeptide 2 / P19099* / P15538* / CYP11B1* / cytochrome P450 family 11 subfamily B member 1* / cytochrome P450 family 11 subfamily B member 2*ENSMUSG0000002258981
Q9QZ82 / Cyp11a1 / Cholesterol side-chain cleavage enzyme, mitochondrial / P05108* / cytochrome P450 family 11 subfamily A member 1*ENSMUSG0000003232334
O35084 / Cyp27b1 / 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial / O15528* / cytochrome P450 family 27 subfamily B member 1*ENSMUSG0000000672427
Q64441 / Cyp24a1 / 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / Q07973* / cytochrome P450 family 24 subfamily A member 1*ENSMUSG0000003856725
Q9DBG1 / Cyp27a1 / Sterol 26-hydroxylase, mitochondrial / Q02318* / cytochrome P450 family 27 subfamily A member 1*ENSMUSG0000002617024
P36423 / Tbxas1 / thromboxane A synthase 1, platelet / P24557* / thromboxane A synthase 1*ENSMUSG0000002992522
Q64459 / Cyp3a11 / Cytochrome P450 3A11 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000005603521
O09158 / Cyp3a25 / Cytochrome P450 3A25 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000002963020
Q64464 / Cyp3a13 / Cytochrome P450 3A13 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000002972720
Q64481 / Cyp3a16 / Cytochrome P450 3A16 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000003865620
Cyp3a44 / cytochrome P450, family 3, subfamily a, polypeptide 44 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000005441720
Cyp3a59 / cytochrome P450, family 3, subfamily a, polypeptide 59 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000006129220
Cyp3a57 / cytochrome P450, family 3, subfamily a, polypeptide 57 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000007041920
Q9JMA7 / Cyp3a41a / Cytochrome P450 3A41 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P45...ENSMUSG0000007555120
Q9JMA7 / Cyp3a41b / Cytochrome P450 3A41 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P45...ENSMUSG0000007555220
Q9WVK8 / Cyp46a1 / Cholesterol 24-hydroxylase / Q9Y6A2* / cytochrome P450 family 46 subfamily A member 1*ENSMUSG0000002125919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002399  Cytochrome P450, mitochondrial
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002017 regulation of blood volume by renal aldosterone ISO
 biological_processGO:0006700 C21-steroid hormone biosynthetic process ISO
 biological_processGO:0006704 glucocorticoid biosynthetic process IMP
 biological_processGO:0032342 aldosterone biosynthetic process ISO
 biological_processGO:0034650 cortisol metabolic process IBA
 biological_processGO:0055075 potassium ion homeostasis ISO
 biological_processGO:0055078 sodium ion homeostasis ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004507 steroid 11-beta-monooxygenase activity ISO
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047783 corticosterone 18-monooxygenase activity IDA


Pathways (from Reactome)
Pathway description
Mineralocorticoid biosynthesis
Glucocorticoid biosynthesis
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000635 pituitary gland hyperplasia "increased size of pituitary gland due to increased cell number" [J:63229, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003353 decreased circulating renin level "reduced blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004119 hypokalemia "excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004906 enlarged uterus 
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009078 adrenal gland hyperplasia "overdevelopment or increased size, usually due to a increased number of cells, of the endocrine glands located above the kidney and responsible for hormone and epinephrine secretion" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009221 uterus adenomyosis "a benign invasion of myometrium by endometrial tissue" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011541 decreased urine aldosterone level "a reduced amount of aldosterone in the urine compared to the normal state" [MGI:anna]
Show

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011546 increased urine progesterone level "an increased amount of progesterone in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011550 decreased urine corticosterone level "a reduced amount of corticosterone in the urine compared to the normal state" [MGI:anna]
Show

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011553 increased urine deoxycorticosterone level "an increased amount of deoxycorticosterone in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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