Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000018	small ears	"outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0000019	thick ears	"increased width of the epidermal and cartilaginous tissue that makes up the ear" [J:65045]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0000020	scaly ears	"ears covered with shedding scales or flakes" [J:65045]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Foxp3^m1Btlr/Y Genetic Background: C57BL/6J-Foxp3^m1Btlr
MP:0000418	patchy hair	"uneven spots of hair growth on the body" [J:26975]	Show Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000420	ruffled hair	"fuzzy, irregular appearance of the hair" [J:50844]	Show Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000465	gastrointestinal hemorrhage	"bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0000491	crypt abscesses	"an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^tm1Tch/Foxp3⁺ Genetic Background: C.129X1-Foxp3^tm1Tch
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0000602	enlarged sinusoidal spaces	"larger than normal sized cavities in the liver " [J:23170]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0000611	jaundice	"clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J Allelic Composition: Foxp3^tm1Ayr/Y,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6 Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0000696	abnormal Peyer s patches morphology	"anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J Allelic Composition: Foxp3^tm1Ayr/Y,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6 Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch
MP:0000753	paralysis	"loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0001116	small gonad	"reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0001145	abnormal male reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0001192	scaly skin	"skin covered with shedding scales or flakes" [J:65146]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J Allelic Composition: Foxp3^sf/0 Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6 Allelic Composition: Foxp3^m1Btlr/Y Genetic Background: C57BL/6J-Foxp3^m1Btlr
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: Foxp3^tm1Ayr/Y,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr,Mir146^tm1.1Bal/Mir146^tm1.1Bal Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Socs1^tm1Ayos/Socs1^tm1Ayos,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001198	tight skin	"skin has a taut, stretched appearance" [J:65038]	Show Allelic Composition: Foxp3^sf/0 Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0001212	skin lesions	"focal patches of inflammation on the skin" [J:30162]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: Foxp3^m1Btlr/Y Genetic Background: C57BL/6J-Foxp3^m1Btlr Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0001222	epidermal hyperplasia	"increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J Allelic Composition: Foxp3^tm1Ayr/Y,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6 Allelic Composition: Foxp3^m1Btlr/Y Genetic Background: C57BL/6J-Foxp3^m1Btlr
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR
MP:0001290	delayed eyelid opening	"late average time for the first postnatal eye opening" [J:17792]	Show Allelic Composition: Foxp3^sf/0 Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR
MP:0001340	abnormal eyelid morphology	"malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Col1a1^{tm1(tetO-EWSR1/ATF1)Yasu}/Col1a1⁺,Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^tm1(EYFP)Cos,Tg(Mpz-cre)94Imeg/0 Genetic Background:* involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Col1a1^{tm1(tetO-EWSR1/ATF1)Yasu}/Col1a1⁺,Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^tm1(EYFP)Cos,Tg(Mpz-cre)94Imeg/0 Genetic Background:* involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch
MP:0001655	multifocal hepatic necrosis	"multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0001764	abnormal homeostasis	"anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il4^tm3.1Kubo/Il4^tm3.1Kubo Genetic Background: B6.Cg-Il4^tm3.1Kubo
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm2Flv/Foxp3⁺ Genetic Background: involves: C57BL/6
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Col2a1^tm1Prc/Col2a1⁺,Col9a1^tm1Jae/Col9a1^tm1Jae Genetic Background: involves: 129/Sv * 129S2/SvPas Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Foxp3^tm1Ayr/Foxp3^tm1Ayr,Tg(Cd4-cre)1Cwi/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Foxp3^tm1Mal/Foxp3^tm1Mal,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001828	abnormal T cell activation	"anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
MP:0001829	increased activated T cell number	"greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001844	autoimmune response	"condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm8Ayr/Y Genetic Background: B6.129-Foxp3^tm8Ayr
MP:0001845	abnormal inflammatory response	"aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Foxp3^tm1Tch/Foxp3⁺ Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0001846	increased inflammatory response	"greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Gt(ROSA)26Sor^tm1Hjf/Gt(ROSA)26Sor⁺,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001852	conjunctivitis	"inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr,Mir146^tm1.1Bal/Mir146^tm1.1Bal Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Socs1^tm1Ayos/Socs1^tm1Ayos,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0001855	atrial thrombosis	"formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0001856	myocarditis	"inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Foxp3^sf/? Genetic Background: Not Specified
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Foxp3^sf/? Genetic Background: Not Specified Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf/J
MP:0001863	vascular inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001869	pancreas inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0001870	salivary gland inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf/J
MP:0001873	stomach inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Shh^tm1Chg/Shh⁺,Sulf1^Gt(XM190)Byg/Sulf1^Gt(XM190)Byg,Sulf2^{Gt(PST111)Byg}/Sulf2^{Gt(PST111)Byg} Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6
MP:0001951	abnormal breathing	"irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt9b^tm1Amc/Wnt9b^tm1Amc Genetic Background: involves: 129X1/SvJ Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6 Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Foxp3^m1Btlr/Y Genetic Background: C57BL/6J-Foxp3^m1Btlr Allelic Composition: Foxp3^tm8Ayr/Y Genetic Background: B6.129-Foxp3^tm8Ayr Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Foxp3^{tm2.1(EGFP/cre)Shori},Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Ifng^tm1Ts/Ifng^tm1Ts,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1Ayr/Foxp3^tm1Ayr,Tg(Cd4-cre)1Cwi/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ Allelic Composition: Foxp3^tm2Ayr/?,Zap70^rps/Zap70^rps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J Allelic Composition: Foxp3^tm1.1Ayr/Y,Rag1^tm1Mom/Rag1^tm1Mom,Tg(TcraTcrb)425Cbn/0 Genetic Background: Not Specified Allelic Composition: Foxp3^tm2Ayr/Foxp3^tm2Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Foxp3^tm2Ayr/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Foxp3^tm1Flv/Foxp3⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Foxp3^tm1Tch/Foxp3⁺ Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm2Flv/Foxp3⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Foxp3^m1Btlr/Foxp3⁺ Genetic Background: C57BL/6J-Foxp3^m1Btlr Allelic Composition: Foxp3^tm8Ayr/Foxp3⁺ Genetic Background: B6.129-Foxp3^tm8Ayr
MP:0002221	abnormal lymph organ size	"change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002281	abnormal respiratory mucosa goblet cell morphology	"structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^tm1Tch/Foxp3⁺ Genetic Background: C.129X1-Foxp3^tm1Tch
MP:0002286	cryptorchism	"failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0002339	abnormal lymph node morphology	"anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0002344	abnormal lymph node B cell domain	"anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002347	abnormal lymph node T cell domain	"anomaly in the area of the lymph node in which T lymphocytes reside" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002357	abnormal spleen white pulp morphology	"anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002371	abnormal thymus cortex morphology	"anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002376	abnormal dendritic cell physiology	"failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]	Show Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002378	abnormal gut-associated lymphoid tissue morphology	"anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxp3^tm6.2Ayr/Foxp3^tm6.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002405	respiratory system inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch
MP:0002408	abnormal double-positive T cell	"anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm2Ayr/?,Zap70^rps/Zap70^rps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002413	abnormal megakaryoblast morphology/development	"anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002424	abnormal reticulocyte morphology/development	"anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0002432	abnormal CD4+ T cell morphology/development	"anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf Allelic Composition: Foxp3^tm2Ayr/?,Zap70^rps/Zap70^rps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002435	abnormal effector T cell morphology/development	"anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: involves: BALB/cJ
MP:0002446	abnormal macrophage morphology	"anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002447	abnormal erythrocyte morphology	"structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002461	increased circulating immunoglobulin concentration	"greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0002495	increased IgA	"greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002497	increased IgE	"greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002534	type IV hypersensitivity reaction	"an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002599	increased mean platelet volume	"increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf
MP:0002619	abnormal lymphocyte morphology/development	"anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002642	anisocytosis	"blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002643	poikilocytosis	"blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0002670	absent scrotum	"missing the external sac of skin that encloses the testes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch
MP:0002771	absent coagulating gland	"missing anterior lobe of the prostate" [J:78062, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR
MP:0002816	colitis	"local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y,Stat6^tm1Gru/Stat6^tm1Gru Genetic Background: C.129-Stat6^tm1Gru Foxp3^tm1Tch Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf
MP:0003292	melena	"dark colored, foul-smelling feces due to the presence of blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0003427	parakeratosis	"abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0003550	short perineum	"reduced length of the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0003642	absent seminal gland	"absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: STOCK MR
MP:0003725	increased autoantibody level	"elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6 Allelic Composition: Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0003786	premature aging	"earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]	Show Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr,Mir146^tm1.1Bal/Mir146^tm1.1Bal Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003853	dry skin	"skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^m1Btlr/Y Genetic Background: C57BL/6J-Foxp3^m1Btlr
MP:0003865	lymph node inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003936	abnormal reproductive system development	"developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^m1Btlr/Y Genetic Background: C57BL/6J-Foxp3^m1Btlr
MP:0003944	abnormal T cell subpopulation ratio	"deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch
MP:0003945	abnormal lymphocyte physiology	"abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr,Mir146^tm1.1Bal/Mir146^tm1.1Bal Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004392	abnormal CD8-positive T cell physiology	"abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6
MP:0004799	increased susceptibility to experimental autoimmune encephalomyelitis	"greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nefm^tm1Ral/Nefm^tm1Ral Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster) Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3⁺,Gpr174^tm1Cys/Gpr174⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0004941	abnormal regulatory T cell morphology	"any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Foxp3^tm7.2Ayr/Foxp3^tm7.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ Allelic Composition: Foxp3^tm1.1Vbo/Foxp3^tm1.1Vbo Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Nr4a2^tm1.1Pcn/Nr4a2⁺,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺,Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004946	abnormal regulatory T cell physiology	"any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1Mal/Foxp3^tm1Mal,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Foxp3^tm2Ayr/Foxp3⁺,Rnf128^tm1Cdon/Rnf128^tm1Cdon Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺,Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004947	skin inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf/J
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0004969	pale kidney	"kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0004972	abnormal regulatory T cell number	"deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm2Ayr/?,Zap70^rps/Zap70^rps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004973	increased regulatory T cell number	"greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Icos^tm1Dgry/Icos^tm1Dgry Genetic Background: B6.129P2-Icos^tm1Dgry Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Foxp3^tm1Kuch/?,Il6^tm1Kopf/Il6^tm1Kopf Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr,Mir146^tm1.1Bal/Mir146^tm1.1Bal Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Socs1^tm1Ayos/Socs1^tm1Ayos,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: B9d2/Tgfb1^tm1Flv/B9d2⁺,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Foxp3^tm1.1Vbo/Foxp3^tm1.1Vbo Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Bcl2l11^tm6.1Boui/Bcl2l11^tm6.1Boui,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004974	decreased regulatory T cell number	"reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1Mal/Foxp3^tm1Mal,Lat^tm1Mal/Lat^tm1Mal Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Foxp3^tm7.2Ayr/Foxp3^tm7.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ Allelic Composition: Foxp3^tm7.2Ayr/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ Allelic Composition: Foxp3^tm6.2Ayr/Foxp3^tm6.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ Allelic Composition: Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ Allelic Composition: Foxp3^{tm1(CD2/CD52)Shori}/Foxp3^{tm1(CD2/CD52)Shori} Genetic Background: involves: C57BL/6 Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y Genetic Background: involves: 129 * C57BL/6
MP:0004975	absent regulatory T cells	"absence of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch
MP:0005010	abnormal CD8+ T cell morphology/development	"anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y,Stat6^tm1Gru/Stat6^tm1Gru Genetic Background: C.129-Stat6^tm1Gru Foxp3^tm1Tch Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm3Tch/Foxp3⁺ Genetic Background: C.129X1-Foxp3^tm3Tch
MP:0005036	diarrhea	"abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1Ayr/Foxp3^tm1Ayr,Tg(Cd4-cre)1Cwi/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005097	polychromatophilia	"condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005156	bradykinesia	"decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]	Show Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^m1Btlr/Y Genetic Background: C57BL/6J-Foxp3^m1Btlr
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0005232	abnormal mesenteric lymph node morphology	"anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0005251	blepharitis	"inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr,Mir146^tm1.1Bal/Mir146^tm1.1Bal Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Socs1^tm1Ayos/Socs1^tm1Ayos,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0005287	narrow eye opening	"less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0005348	increased T cell proliferation	"increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0005350	increased susceptibility to autoimmune disorders	"greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J Allelic Composition: Foxp3^tm1Ayr/Y,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm1.1Ayr/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0005463	abnormal CD4+ T cell physiology	"anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm2Flv/Y Genetic Background: involves: C57BL/6 Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Foxp3^tm3Tch/Foxp3⁺ Genetic Background: C.129X1-Foxp3^tm3Tch Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf
MP:0005466	abnormal T helper 2 physiology	"anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005617	increased susceptibility to type IV hypersensitivity reaction	"greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dazap1^tm1.2Pyen/Dazap1^tm1.2Pyen Genetic Background: involves: 129S6/SvEvTac
MP:0005639	hemosiderosis	"condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0006413	increased T cell apoptosis	"increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm3Tch/Foxp3⁺ Genetic Background: C.129X1-Foxp3^tm3Tch
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Ifng^tm1Ts/Ifng^tm1Ts,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxp3^tm2Ayr/?,Zap70^rps/Zap70^rps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008076	abnormal CD4-positive T cell differentiation	"atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1Kuch/?,Il6^tm1Kopf/Il6^tm1Kopf Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Ifng^tm1Ts/Ifng^tm1Ts,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm2Ayr/?,Zap70^rps/Zap70^rps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008092	abnormal T-helper 2 cell differentiation	"atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008097	increased plasma cell number	"greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008102	lymph node hyperplasia	"overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0008126	increased dendritic cell number	"greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008234	absent spleen marginal zone	"absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0008255	decreased megakaryocyte cell number	"reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf
MP:0008397	abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology	"any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Pon1^tm1Lus/Pon1^tm1Lus Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0008475	intermingled spleen red and white pulp	"no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0008478	increased spleen white pulp amount	"increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0008499	increased IgG1 level	"greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch
MP:0008559	abnormal interferon-gamma secretion	"anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008566	increased interferon-gamma secretion	"increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr,Mir146^tm1.1Bal/Mir146^tm1.1Bal Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008568	abnormal interleukin secretion	"anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008577	increased circulating interferon-gamma level	"increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y,Stat6^tm1Gru/Stat6^tm1Gru Genetic Background: C.129-Stat6^tm1Gru Foxp3^tm1Tch
MP:0008593	increased circulating interleukin-10 level	"increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch
MP:0008597	decreased circulating interleukin-6 level	"reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Foxp3^tm1Kuch/?,Il6^tm1Kopf/Il6^tm1Kopf Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008602	increased circulating interleukin-4 level	"increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch
MP:0008626	increased circulating interleukin-5 level	"increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch
MP:0008660	increased interleukin-10 secretion	"increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008661	decreased interleukin-10 secretion	"reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008672	increased interleukin-13 secretion	"increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008681	increased interleukin-17 secretion	"increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008682	decreased interleukin-17 secretion	"reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]	Show Allelic Composition: Foxp3^tm1Kuch/?,Il6^tm1Kopf/Il6^tm1Kopf Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008687	increased interleukin-2 secretion	"increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0008698	abnormal interleukin-4 secretion	"anomaly in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N Allelic Composition: Drosha^tm1Litt/Drosha^tm1.1Litt,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
MP:0008699	increased interleukin-4 secretion	"increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008702	increased interleukin-5 secretion	"increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008705	increased interleukin-6 secretion	"increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008721	abnormal chemokine level	"deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch
MP:0008751	abnormal interleukin level	"deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008752	abnormal tumor necrosis factor level	"deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008826	abnormal splenic cell ratio	"deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Ctla4^tm1Saka/Ctla4^tm1Saka,Foxp3^tm1(cre)Saka/Y Genetic Background: involves: BALB/c
MP:0008894	abnormal intraepithelial T cell morphology	"any structural anomaly of a T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]	Show Allelic Composition: Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0009675	orthokeratosis	"thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^{tm3(DTR/GFP)Ayr}/Foxp3^{tm3(DTR/GFP)Ayr} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009931	abnormal skin appearance	"skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0010169	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf
MP:0010334	pleural effusion	"accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0011015	decreased body surface temperature	"reduced degree of heat natural to skin-environment interface of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0011083	complete lethality at weaning	"premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR Allelic Composition: Foxp3^tm1Tch/Y,Stat6^tm1Gru/Stat6^tm1Gru Genetic Background: C.129-Stat6^tm1Gru Foxp3^tm1Tch
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: C.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm1Tch/Y Genetic Background: B6.129X1-Foxp3^tm1Tch Allelic Composition: Foxp3^tm3Tch/Y Genetic Background: C.129X1-Foxp3^tm3Tch
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl
MP:0011224	abnormal lymph node medullary cord morphology	"any structural anomaly of the dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node" [ISBN:0-683-40008-8]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0011237	decreased blood oxygen capacity	"a decrease in the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood" [ISBN:0-683-40008-8]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0011887	decreased circulating lipase level	"reduced blood level of lipase in the blood, in particular the serum" [MGI:csmith]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0012078	abnormal tail ring morphology	"any structural anomaly of the segmentally patterned skin ridges appearing on the tail of rodents" [MGI:csmith]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0012188	increased regulatory T cell apoptosis	"increase in the number of regulatory T cells undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta,Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0012246	abnormal hepatic cord morphology	"any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [MGI:anna]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: either: 129Rl.Cg-Foxp3^sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)
MP:0013295	pancreas atrophy	"acquired size diminution of any portion of the pancreas, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0013772	increased effector memory T-helper cell number	"increase in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [MGI:Saran]	Show Allelic Composition: Foxp3^{tm2.1(EGFP/cre)Shori}/Y,Pdcd1^tm1Hon/Pdcd1^tm1Hon Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr

ENSMUSG00000039521