Manteia

ENSMUSG00000040356

Mus musculus

Features

Gene ID:	ENSMUSG00000040356

Biological name :	Skiv2l

Synonyms :	Skiv2l / superkiller viralicidic activity 2-like (S. cerevisiae)

Possible biological names infered from orthology :	Q15477 / Ski2 like RNA helicase

Species:	Mus musculus

Chr. number:	17
Strand:	-1
Band:	B1
Gene start:	34839228
Gene end:	34850210

Corresponding Affymetrix probe sets:	10450296 (MoGene1.0st) 1422584_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000036265 Ensembl peptide - ENSMUSP00000134209 Ensembl peptide - ENSMUSP00000134294 NCBI entrez gene - 108077 See in Manteia. MGI - MGI:1099835 RefSeq - XM_017317205 RefSeq - NM_021337 RefSeq Peptide - NP_067312 swissprot - G3UYT1 swissprot - Q6NZR5 swissprot - G3UZ05 Ensembl - ENSMUSG00000040356

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q9CZU3 / Skiv2l2 / Superkiller viralicidic activity 2-like 2 / MTREX* / P42285* / Mtr4 exosome RNA helicase*	ENSMUSG00000016018	30
Ddx60 / DExD/H-box helicase 60 / Q8IY21*	ENSMUSG00000037921	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR001650	Helicase, C-terminal
IPR011545	DEAD/DEAH box helicase domain
IPR012961	ATP-dependent RNA helicase Ski2, C-terminal
IPR014001	Helicase superfamily 1/2, ATP-binding domain
IPR016438	ATP-dependent RNA helicase Ski2-like
IPR025696	rRNA-processing arch domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006401	RNA catabolic process	IEA
biological_process	GO:0070478	nuclear-transcribed mRNA catabolic process, 3"-5" exonucleolytic nonsense-mediated decay	IBA
cellular_component	GO:0055087	Ski complex	ISO
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0003724	RNA helicase activity	IEA
molecular_function	GO:0004004	ATP-dependent RNA helicase activity	IBA
molecular_function	GO:0005524	ATP binding	IEA

Pathways (from Reactome)

Pathway description

mRNA decay by 3 to 5 exoribonuclease

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001415	increased exploration in new environment	"greater amount of time spent investigating new location" [J:28825]	Show Allelic Composition: Scrib^{tm1b(NCOM)Mfgc}/Scrib^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Scrib^{tm1a(NCOM)Mfgc}/Tcp
MP:0011095	complete embryonic lethality between implantation and placentation	"death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]	Show Allelic Composition: Hsp90aa1^{Tg(Tyr)2396BOve}/Hsp90aa1^{Tg(Tyr)2396BOve} Genetic Background: FVB/N-Hsp90aa1^{Tg(Tyr)2396BOve}
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rad9a^{tm1.1(KOMP)Wtsi}/Rad9a^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad9a^{tm1.1(KOMP)Wtsi}/Bay

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000019977	Hbs1l / Q69ZS7 / HBS1-like protein / Q9Y450* / HBS1 like translational GTPase*	/ complex
ENSMUSG00000061559	Wdr61 / Q9ERF3 / WD repeat domain 61 / Q9GZS3*	/ complex
ENSMUSG00000033991	Ttc37 / tetratricopeptide repeat domain 37 / Q6PGP7*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr