ENSMUSG00000041710


Mus musculus

Features
Gene ID: ENSMUSG00000041710
  
Biological name :Trpc5
  
Synonyms : Q9QX29 / transient receptor potential cation channel, subfamily C, member 5 / Trpc5
  
Possible biological names infered from orthology : Q9UL62
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F2
Gene start: 144381671
Gene end: 144688180
  
Corresponding Affymetrix probe sets: 10607169 (MoGene1.0st)   1422048_at (Mouse Genome 430 2.0 Array)   1442589_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049063
NCBI entrez gene - 22067     See in Manteia.
MGI - MGI:109524
RefSeq - NM_009428
RefSeq Peptide - NP_033454
swissprot - Q2KHN9
swissprot - Q9QX29
Ensembl - ENSMUSG00000041710
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpc5aENSDARG00000070504Danio rerio
 trpc5bENSDARG00000060837Danio rerio
 TRPC5ENSGALG00000007972Gallus gallus
 TRPC5ENSG00000072315Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpc4 / Q9QUQ5 / transient receptor potential cation channel, subfamily C, member 4 / Q9UBN4*ENSMUSG0000002774866
Trpc1 / transient receptor potential cation channel, subfamily C, member 1 / P48995*ENSMUSG0000003283935
Trpc3 / transient receptor potential cation channel, subfamily C, member 3 / Q13507*ENSMUSG0000002771633
Trpc7 / Q9WVC5 / transient receptor potential cation channel, subfamily C, member 7 / Q9HCX4*ENSMUSG0000002154132
Trpc6 / Q61143 / transient receptor potential cation channel, subfamily C, member 6 / Q9Y210*ENSMUSG0000003199732
Xntrpc / Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthroughENSMUSG0000007042528
Trpc2 / Q9R244 / Short transient receptor potential channel 2 ENSMUSG0000010025428


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR002153  Transient receptor potential channel, canonical
 IPR004729  Transient receptor potential channel
 IPR005461  Transient receptor potential channel, canonical 5
 IPR005821  Ion transport domain
 IPR013555  Transient receptor ion channel domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006828 manganese ion transport IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:1902630 regulation of membrane hyperpolarization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0034704 calcium channel complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015279 store-operated calcium channel activity IBA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0042805 actinin binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IDA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trpc5tm1.1Clph/Y
Genetic Background: involves: 129S1/SvImJ

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Bbs1tm2Vcs/Bbs1tm2Vcs,Tg(Pdgfra-cre)1Clc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Trpc5tm1.1Lbi/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
Show

Allelic Composition: Bbs1tm2Vcs/Bbs1tm2Vcs,Tg(Pdgfra-cre)1Clc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Trpc5tm1.1Lbi/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trpc5tm1.1Clph/Y
Genetic Background: involves: 129S1/SvImJ

 MP:0003459 increased fear-related response "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trpc5tm1.1Clph/Y
Genetic Background: involves: 129S1/SvImJ

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trpc5tm1.1Clph/Y
Genetic Background: involves: 129S1/SvImJ

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbs1tm2Vcs/Bbs1tm2Vcs,Tg(Pdgfra-cre)1Clc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Trpc5tm1.1Lbi/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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