ENSMUSG00000100254


Mus musculus

Features
Gene ID: ENSMUSG00000100254
  
Biological name :Trpc2
  
Synonyms : Q9R244 / Short transient receptor potential channel 2 / Trpc2
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 102083116
Gene end: 102096396
  
Corresponding Affymetrix probe sets: 1425672_a_at (Mouse Genome 430 2.0 Array)   1430485_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116934
NCBI entrez gene - 22064     See in Manteia.
MGI - MGI:109527
RefSeq - NM_001109897
RefSeq Peptide - NP_001103367
swissprot - Q9R244
Ensembl - ENSMUSG00000100254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpc2aENSDARG00000039065Danio rerio
 trpc2bENSDARG00000003344Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Xntrpc / Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthroughENSMUSG00000070425100
Trpc7 / Q9WVC5 / transient receptor potential cation channel, subfamily C, member 7 / Q9HCX4*ENSMUSG0000002154132
Trpc3 / transient receptor potential cation channel, subfamily C, member 3 / Q13507*ENSMUSG0000002771632
Trpc6 / Q61143 / transient receptor potential cation channel, subfamily C, member 6 / Q9Y210*ENSMUSG0000003199732
Trpc4 / Q9QUQ5 / transient receptor potential cation channel, subfamily C, member 4 / Q9UBN4*ENSMUSG0000002774831
Trpc5 / Q9QX29 / transient receptor potential cation channel, subfamily C, member 5 / Q9UL62*ENSMUSG0000004171030
Trpc1 / transient receptor potential cation channel, subfamily C, member 1 / P48995*ENSMUSG0000003283927


Protein motifs (from Interpro)
Interpro ID Name
 IPR002153  Transient receptor potential channel, canonical
 IPR005458  Transient receptor potential channel, canonical 2
 IPR005821  Ion transport domain
 IPR013555  Transient receptor ion channel domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair IEA
 biological_processGO:0002121 inter-male aggressive behavior IMP
 biological_processGO:0002124 territorial aggressive behavior IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0006828 manganese ion transport IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IPI
 biological_processGO:0007340 acrosome reaction IMP
 biological_processGO:0008050 female courtship behavior IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0019236 response to pheromone IMP
 biological_processGO:0048047 mating behavior, sex discrimination IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:1902436 negative regulation of male mating behavior IGI
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0012505 endomembrane system IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032590 dendrite membrane IMP
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0015279 store-operated calcium channel activity IDA
 molecular_functionGO:0019992 diacylglycerol binding IMP
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001355 submission towards males "no domineering, assault posture nor hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9, J:60896]
Show

Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001375 abnormal mating preference "deviation from the usual preference of a male to initiate sexual contact with a receptive female; usually refers to males that initiate sexual behavior with males and females indiscriminately" [J:76339]
Show

Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

Allelic Composition: Gucy1b2tm3Mom/Gucy1b2tm3Mom,Trpc2tm1Mom/Trpc2tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002243 abnormal vomeronasal organ morphology "any structural anomaly of the specialized portion of the nasal septum that is composed of chemosensitive cells and lies anteriorly in the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pkd1tm1Gztn/Pkd1tm1Gztn,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv

 MP:0009945 abnormal accessory olfactory bulb morphology "any structural anomaly of the forebrain region that coordinates sensory signaling arising from the vomeronasal organ; it is located on the dorsal-posterior portion of the main olfactory bulb, and the axons that leave the accessory olfactory bulb project to targets in the amygdala and hypothalamus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011176 abnormal erythroblast morphology "any structural anomaly of the nucleated precursor of erythrocytes" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv

 MP:0011677 abnormal olfactory sensory neuron physiology "any functional anomaly of cells that innervate the olfactory epithelium and are responsible for receiving and transmitting odorant signals" [MGI:csmith]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

Allelic Composition: Gucy1b2tm3Mom/Gucy1b2tm3Mom,Trpc2tm1Mom/Trpc2tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom,Trpc2tm2Mom/Trpc2tm2Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Y,Trpc2tm2Mom/Trpc2tm2Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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